Evidence map›Paper›PMID 34135059›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance.

Fan Sun, Liwen Li, Yadong Xiao, Alyssa D Gregory, Steven D Shapiro, Gutian Xiao, Zhaoxia Qu

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. PDLIM2 in Lung Adenocarcinoma Metastasis.bioRxiv : the preprint server for biology · 2025
    Article
  4. PDLIM2 Repression: A Common Mechanism in Viral Lung Infection.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. PDLIM2: Signaling pathways and functions in cancer suppression and host immunity.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fan SunUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.
Liwen LiUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.
Yadong XiaoUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.
Alyssa D GregoryDepartment of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA.
Steven D ShapiroUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA; shapirosd@upmc.edu xiaog2@upmc.edu quz@upmc.edu.
Gutian XiaoUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA; shapirosd@upmc.edu xiaog2@upmc.edu quz@upmc.edu.
Zhaoxia QuUPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA; shapirosd@upmc.edu xiaog2@upmc.edu quz@upmc.edu.

Funding

Mechanistic difference of NF-kappaB in lung physiology and tumorigenesisR01CA258614 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zhaoxia Qu, GUTIAN XIAO · 2022 to 2026
$1.9M
PDLIM2 as a cancer and chemosensitizing targetR01CA172090 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIAO, GUTIAN · 2013 to 2017
$1.6M
Faithful Mouse Modeling of Human Lung CancerR21CA259706 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI XIAO, GUTIAN · 2021 to 2021
$405k
NCI NIH HHS R01 CA172090NCI NIH HHS R01 CA258614NCI NIH HHS R21 CA259706
6 · The paper itself

Abstract

Macrophages play a central role in lung physiology and pathology. In this study, we show in mice that alveolar macrophages (AMs), unlike other macrophage types (interstitial, peritoneal, and splenic macrophages), constitutively express programmed death-1 ligand 1 (PD-L1), thereby possessing a superior phagocytic ability and the capacity to repress CTLs by

Indexed as

AnimalsB7-1 AntigenB7-H1 AntigenMacrophages, AlveolarMiceMice, Inbred StrainsMice, KnockoutB7-1 AntigenB7-H1 AntigenCd274 protein, mouse

Identifiers

PMID34135059
PMCPMC8674373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.