Evidence map›Paper›PMID 34135015›Full record

Trial reportDiabetes care2021

Effect of Medical and Surgical Interventions on α-Cell Function in Dysglycemic Youth and Adults in the RISE Study.

Steven E Kahn, Sharon L Edelstein, Silva A Arslanian, Elena Barengolts, Sonia Caprio, David A Ehrmann, Tamara S Hannon, Santica Marcovina, Kieren J Mather, Kristen J Nadeau and 5 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Steven E KahnVA Puget Sound Health Care System, Seattle, WA.ORCID 0000-0001-7307-9002
Sharon L EdelsteinBiostatistics Center, The George Washington University, Rockville, MD rise@bsc.gwu.edu.ORCID 0000-0001-8457-4404
Silva A ArslanianUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-1528-9324
Elena BarengoltsJesse Brown VA Medical Center, Chicago, IL.
Sonia CaprioYale University, New Haven, CT.ORCID 0000-0002-7523-5053
David A EhrmannUniversity of Chicago, Chicago, IL.
Tamara S HannonIndiana University School of Medicine, Indianapolis, IN.
Santica MarcovinaUniversity of Washington, Seattle, WA.
Kieren J MatherIndiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-8696-7500
Kristen J NadeauUniversity of Colorado Denver, Aurora, CO.ORCID 0000-0002-0477-3356
Kristina M UtzschneiderVA Puget Sound Health Care System, Seattle, WA.
Anny H XiangKaiser Permanente Southern California, Pasadena, CA.ORCID 0000-0003-2786-1268
Thomas A Buchanan
RISE Consortium
Rise Consortium Investigators:
University of Washington · USIndiana University School of MedicineVA Puget Sound Health Care System · USChildren's Hospital of Pittsburgh · USGeorge Washington University · USJesse Brown VA Medical Center · USKaiser Permanente · USUniversity of Chicago · USUniversity of Colorado Denver · USUniversity of Southern California · USYale University · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI GRAEME I BELL, Raghavendra G Mirmira · 2013 to 2026
$20.9M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tamara S Hannon · 2015 to 2026
$17.4M
NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Maki Nakayama · 2020 to 2026
$10.8M
NCATS NIH HHS TL1 TR001858NCATS NIH HHS UL1 TR000430NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K24 HL145076NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK097512NIDDK NIH HHS P30 DK116073NIDDK NIH HHS U01 DK094406NIDDK NIH HHS U01 DK094430NIDDK NIH HHS U01 DK094431NIDDK NIH HHS U01 DK094438NIDDK NIH HHS U01 DK094467
6 · The paper itself

Abstract

objectiveTo compare effects of medications and laparoscopic gastric band surgery (LB) on α-cell function in dysglycemic youth and adults in the Restoring Insulin Secretion (RISE) Study protocols. RESEARCH DESIGN AND

methodsGlucagon was measured in three randomized, parallel, clinical studies:

resultsNo change in fasting glucagon, steady-state glucagon, or AGR was seen at 12 months following treatment with MET or G/M (in youth and adults) or PLAC (in adults). In contrast, L+M reduced these measures at 12 months (all

conclusionsGlucagon concentrations were reduced by L+M and LB in adults with dysglycemia, an effect principally attributable to weight loss in both interventions.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceAdolescentAdultBlood GlucoseGlucose Tolerance TestHumansInsulinInsulin SecretionBlood GlucoseInsulin

Identifiers

PMID34135015
PMCPMC8740921
OpenAlexW3171389780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.