Evidence map›Paper›PMID 34135000›Full record

ArticleCancer research2021

An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.

Ghada M Sharif, Moray J Campbell, Apsra Nasir, Surojeet Sengupta, Garrett T Graham, Max H Kushner, William B Kietzman, Marcel O Schmidt, Gray W Pearson, Olivier Loudig and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Advancements in Zebrafish Models for Breast Cancer Research: Unveiling Biomarkers, Targeted Therapies, and Personalized Medicine.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Ghada M SharifLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
Moray J CampbellDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-3355-0928
Apsra NasirLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
Surojeet SenguptaThe Hormel Institute, University of Minnesota, Medical Research Center, Austin, Minnesota.
Garrett T GrahamLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.ORCID 0000-0002-1097-0962
Max H KushnerLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
William B KietzmanLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
Marcel O SchmidtLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.ORCID 0000-0002-3991-2766
Gray W PearsonLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
Olivier LoudigHackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey.
Susan FinebergDepartment of Pathology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York.
Anton WellsteinLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.ORCID 0000-0002-0570-4950
Anna T RiegelLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia. ariege01@georgetown.edu.
Georgetown University · USAlbert Einstein College of Medicine · USCenter for Discovery · USHormel (United States) · USThe Ohio State University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
(PQ6) Molecular Mechanisms Driving Benign to Malignant Transitions in Breast CancerR01CA205632 · NCI · GEORGETOWN UNIVERSITY · PI RIEGEL, ANNA TATE · 2016 to 2020
$2.3M
DEFINING HOW COOPERATION BETWEEN TUMOR SUBPOPULATIONS PROMOTES TUMOR PROGRESSIONR01CA218670 · NCI · GEORGETOWN UNIVERSITY · PI PEARSON, GRAY W · 2017 to 2021
$1.8M
Development of clinically relevant models of DCISR21CA226542 · NCI · GEORGETOWN UNIVERSITY · PI RIEGEL, ANNA TATE · 2019 to 2020
$369k
Role of AIB1 in YAP/TAZ-TEAD signaling in progression of early stage breast cancerF31CA232664 · NCI · GEORGETOWN UNIVERSITY · PI KUSHNER, MAX HARLEY · 2018 to 2019
$50k
NCI NIH HHS F31 CA232664NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA205632NCI NIH HHS R01 CA218670NCI NIH HHS R21 CA226542NCI NIH HHS T32 CA009686
6 · The paper itself

Abstract

AIB1Δ4 is an N-terminally truncated isoform of the oncogene amplified in breast cancer 1 (AIB1) with increased expression in high-grade human ductal carcinoma

Indexed as

AnimalsCell Culture Techniques, Three DimensionalCell Line, TumorCRISPR-Cas SystemsDexamethasoneDisease ProgressionElectric ImpedanceEnhancer Elements, GeneticFemaleHumansLung NeoplasmsMiceMice, SCIDNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationDexamethasoneefatutazoneNCOA3 protein, humanNcoa3 protein, mouseNuclear Receptor Coactivator 3Protein IsoformsReceptors, GlucocorticoidThiazolidinediones

Identifiers

PMID34135000
PMCPMC8373795
OpenAlexW3166167845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.