Evidence map›Paper›PMID 34134981›Full record

ArticleScience advances2021

Hormonal control of motivational circuitry orchestrates the transition to sexuality in

Stephen X Zhang, Ethan H Glantz, Lauren E Miner, Dragana Rogulja, Michael A Crickmore

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. TheProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Review
  20. TheProceedings. Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen X ZhangDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0001-7743-9247
Ethan H GlantzFM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lauren E MinerFM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0003-3756-3248
Dragana RoguljaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. dragana_rogulja@hms.harvard.edu michael.crickmore@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-3535-8745
Michael A CrickmoreFM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. dragana_rogulja@hms.harvard.edu michael.crickmore@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-7175-4745

Funding

Mating behavior in Drosophila as a model for understanding and controlling aberrant dopaminergic responsesDP1DA044358 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI CRICKMORE, MICHAEL A · 2017 to 2021
$2.7M
NIDA NIH HHS DP1 DA044358
6 · The paper itself

Abstract

Newborns and hatchlings can perform incredibly sophisticated behaviors, but many animals abstain from sexual activity at the beginning of life. Hormonal changes have long been known to drive both physical and behavioral changes during adolescence, leading to the largely untested assumption that sexuality emerges from organizational changes to neuronal circuitry. We show that the transition to sexuality in male

Identifiers

PMID34134981
PMCPMC8208730

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.