Evidence map›Paper›PMID 34134959›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Aryl hydrocarbon receptor modulates airway inflammation in mice with cockroach allergen-induced asthma by regulating Th17/Treg differentiation].

T Xu, Z Cui, J Wang, Y Feng, R Xie, D Li, J Peng, R Huang, T Li

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

T XuSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z CuiDepartment of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
J WangSecond Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Y FengSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
R XieSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
D LiSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
J PengSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
R HuangSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
T LiSleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Guangzhou Medical University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether aryl hydrocarbon receptor (AhR) modulates cockroach allergen (CRE)-induced asthma by regulating Th17/Treg differentiation.

objectiveMouse models of CRE-induced asthma established by sensitizing and challenging the mice with CRE were randomized into asthma model group, AhR agonist group treated with TCDD (10 μg/ kg), and AhR antagonist group treated with TCDD and CH223191 (10 mg/kg) (

objectiveBoth TCDD and CH223191 were capable of modulating pulmonary expressions of AhR and its downstream genes Cyp1a1 and Cyp1b1 in asthmatic mice (

objectiveAhR activation modulates airway inflammation in mice with CRE-induced asthma by modulating the differentiation of Th17/Treg.

Indexed as

AsthmaCockroachesAllergensAnimalsCell DifferentiationInflammationMiceReceptors, Aryl HydrocarbonTh17 CellsT-Lymphocytes, RegulatoryAllergensReceptors, Aryl HydrocarbonAryl hydrocarbon receptorasthmacockroach allergenTh17Treg

Identifiers

PMID34134959
PMCPMC8214952
OpenAlexW3168512335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.