Evidence map›Paper›PMID 34134949›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Preparation of doxorubicin-loaded metallic organic nanoparticles and their effect for enhancing efficacy of high-intensity focused ultrasound therapy in tumor-bearing mice].

H Ye, N Huang, T Sun, W Hou, J Bai, H Li

Open access · greenAbstract read
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In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

H YeState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
N HuangState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
T SunState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
W HouState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
J BaiState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
H LiState Key Laboratory of Ultrasound Medical Engineering//College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo prepare metallic organic nanoparticles that produce synergistic effect in high-intensity focused ultrasound (HIFU) therapy of tumors.

objectiveGlucose oxidase (GOD), MnO

objectiveWe successfully prepared GMFD NPs, which had an average particle size of 131.23±0.84 nm with a surface potential of 21.87±1.72 mV. GMFD NPs, with a drug loading rate of 40.18%, was capable of releasing more than 77.2% of the loaded DOX within 4 h in acidic environment. In the tumor-bearing mouse models, HIFU irradiation following GMFD NP injection, as compared with saline injection, resulted in significantly enhanced gray value of the tumor (25.5±4.5

objectiveGMFD NPs prepared in this study can enhance tumor ablation efficacy of HIFU and release DOX for further treatment of the residual tumor tissue in mice.

Indexed as

Extracorporeal Shockwave TherapyNanoparticlesNeoplasmsAnimalsCell Line, TumorDoxorubicinManganese CompoundsMiceMice, NudeOxidesDoxorubicinManganese CompoundsOxidescombined treatmenthigh-intensity focused ultrasoundmetallic organic nanoparticlesMnO2pH response

Identifiers

PMID34134949
PMCPMC8214957
OpenAlexW3167689123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.