Evidence map›Paper›PMID 34134748›Full record

ArticleVeterinary research2021

Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta.

Cynthia Machín, Yolanda Corripio-Miyar, Julia N Hernández, Tara Pérez-Hernández, Adam D Hayward, Harry W Wright, Daniel R G Price, Jacqueline B Matthews, Tom N McNeilly, Alasdair J Nisbet and 1 more

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Variability in the Response againstInternational journal of molecular sciences · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Cynthia MachínFacultad de Veterinaria, Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Universidad de Las Palmas de Gran Canaria, Arucas, Spain.
Yolanda Corripio-MiyarMoredun Research Institute, Edinburgh, UK.
Julia N HernándezFacultad de Veterinaria, Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Universidad de Las Palmas de Gran Canaria, Arucas, Spain. julia.hernandez@ulpgc.es.ORCID http://orcid.org/0000-0002-3843-2509
Tara Pérez-HernándezFacultad de Veterinaria, Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Universidad de Las Palmas de Gran Canaria, Arucas, Spain.
Adam D HaywardMoredun Research Institute, Edinburgh, UK.
Harry W WrightMoredun Research Institute, Edinburgh, UK.
Daniel R G PriceMoredun Research Institute, Edinburgh, UK.
Jacqueline B MatthewsRoslin Technologies, Edinburgh, UK.
Tom N McNeillyMoredun Research Institute, Edinburgh, UK.
Alasdair J NisbetMoredun Research Institute, Edinburgh, UK.
Jorge F GonzálezFacultad de Veterinaria, Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Universidad de Las Palmas de Gran Canaria, Arucas, Spain.
Moredun Research Institute · GBUniversidad de Las Palmas de Gran Canaria · ESRoslin Cells (United Kingdom) · GB

Funding

Agencia Canaria de Investigación, Innovación y Sociedad de la Información TESIS2017010080Cabildo Insular de Gran Canaria PIFCABILDO-2017-CCSALUD-2European Social Fund TESIS2017010080Horizon 2020 635408Universidad de Las Palmas de Gran Canaria PIFCABILDO-2017-CCSALUD-2
6 · The paper itself

Abstract

Due to increased anthelmintic resistance, complementary methods to drugs are necessary to control gastrointestinal nematodes (GIN). Vaccines are an environmentally-friendly and promising option. In a previous study, a Teladorsagia circumcincta recombinant sub-unit vaccine was administered to two sheep breeds with different levels of resistance against GIN. In the susceptible Canaria Sheep (CS) breed, vaccinates harboured smaller worms with fewer eggs in utero than the control group. Here, we extend this work, by investigating the cellular and humoral immune responses of these two sheep breeds following vaccination and experimental infection with T. circumcincta. In the vaccinated CS group, negative associations between antigen-specific IgA, IgG

Indexed as

Immunity, CellularImmunity, HumoralAnimalsSheepSheep DiseasesSheep, DomesticTrichostrongyloideaTrichostrongyloidiasisVaccinationVaccinesVaccinesCellular responseGenetic resistanceGlobule leukocytesImmune responseImmunoglobulinsNematode vaccineSheepTeladorsagia circumcincta

Identifiers

PMID34134748
PMCPMC8207578
OpenAlexW3167063333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.