Evidence map›Paper›PMID 34134738›Full record

Trial reportAIDS research and therapy2021

The transient effect of a peer support intervention to improve adherence among adolescents and young adults failing antiretroviral therapy in Harare, Zimbabwe: a randomized control trial.

Chiratidzo E Ndhlovu, Vinie Kouamou, Primrose Nyamayaro, Leanne Dougherty, Nicola Willis, Bisola O Ojikutu, A Tariro Makadzange

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02833441 nacompletednot on this map

The Peer Support Intervention - Supporting HIV Positive Adolescents in Zimbabwe to Improve HIV Care Continuum Outcomes

TypeinterventionalSponsorUniversity of ZimbabweRan2016 to 2018Enrolled214ConditionsHIVArmsPeer Support
NCT05516602 nacompletednot on this mapstarted 2023, after this paper: background citation

Improving HIV Prevention Among Adolescent Girls and Young Women (AGYW) in Uganda

TypeinterventionalSponsorMRC/UVRI and LSHTM Uganda Research UnitRan2023 to 2024Enrolled394ConditionsHIV-1-infectionArmsPeer Support
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chiratidzo E NdhlovuDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Vinie KouamouDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Primrose NyamayaroDepartment of Psychiatry, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Leanne DoughertyJohn Snow Inc, Boston, MA, USA. ldougherty@popcouncil.org.ORCID 0000-0002-5702-9328
Nicola WillisAfricaid, Harare, Zimbabwe.
Bisola O OjikutuJohn Snow Inc, Boston, MA, USA.
A Tariro MakadzangeDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
University of Zimbabwe · ZWBrigham and Women's Hospital · USJohn Snow (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescents and young adults living with HIV in sub Saharan Africa are at high risk of poor adherence to antiretroviral therapy (ART) and virologic failure (VF).

methodsWe conducted a randomized control trial among adolescents and young adults on ART with VF to assess the effectiveness of a community-based peer support intervention aimed at improving VF. Viral load (VL) levels were obtained at 12, 24 and 36 weeks. A subset of the participants had baseline HIV drug resistance (HIVDR) genotyped using Sanger sequencing.

resultsThe participants' median (interquartile range (IQR)) age was 18.1 (IQR: 15.1-20.0) years and half (50.5%, n = 107) were male. At week 24, the proportion of subjects with a detectable viremia was significantly lower in the intervention arm than in the standard of care (SOC) arm (76.0% (n = 79) vs. 89.0% (n = 96), p = 0.013). At Week 36, there remained a difference in the proportion of subjects with a detectable VL between the intervention arm (68.3%, n = 71) and SOC arm (79.6%, n = 86), which was trending towards statistical significance (p = 0.059). There was no difference in the probability of having a detectable VL over time between the intervention and SOC groups (adjusted odds ratio: 1.14, p = 0.439). Baseline HIVDR was observed in 44.0% of the participants in the intervention and 56.0% in the SOC group (p = 0.146).

conclusionA transient effect of the peer support intervention in improving VF was observed among adolescents and young people failing ART.

trial registrationThis study is registered with www.clinicaltrials.gov under the reference number: NCT02833441.

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentAdultCounselingHumansMaleViral LoadYoung AdultZimbabweAnti-HIV AgentsAdolescentsHIVPeer supportPublic healthSub-Saharan AfricaZimbabwe

Identifiers

PMID34134738
PMCPMC8207727
OpenAlexW3166179389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.