Observational studyRespiratory research2021
Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank.
Observational study in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- SEFA: Semantic Embedding-Based Feature Augmentation of Biomedical Language-Model Embeddings Improves Interpretable Metabolomic Prediction of Lung Cancer.Biomedicines · 2026Article
- Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study.Discover oncology · 2025Article
- Genetically predicted serum urate and cancer risk: a Mendelian randomization study.Scandinavian journal of rheumatology · 2025Article
- Effects of lifestyle and associated diseases on serum CC16 suggest complex interactions among metabolism, heart and lungs.Journal of advanced research · 2024Article
- Causal relationship between genetic-predicted uric acid and cervical cancer risk: evidence for nutritional intervention on cervical cancer prevention.Frontiers in nutrition · 2024Article
- Association between serum uric acid and colorectal cancer risk in European population: a two-sample Mendelian randomization study.Frontiers in oncology · 2024Article
- Mendelian randomization study of the relationship between blood and urine biomarkers and lung cancer.Frontiers in oncology · 2024Article
- Advances in metabolomics of chronic obstructive pulmonary disease.Chinese medical journal pulmonary and critical care medicine · 2023Review
- The value of blood-based measures of liver function and urate in lung cancer risk prediction: A cohort study and health economic analysis.Cancer epidemiology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum urate is the most abundant small molecule with antioxidant properties found in blood and the epithelial lining fluid of the respiratory system. Moderately raised serum urate is associated with lower rates of lung cancer and COPD in smokers but whether these relationships reflect antioxidant properties or residual confounding is unknown.
methodsWe investigated the observational and potentially causal associations of serum urate with lung cancer incidence and FEV
resultsThe analysis included 359,192 participants and 1,924 lung cancer events. The associations between measured urate levels and lung cancer were broadly U-shaped but varied by sex at birth with the strongest associations in current smoking men. After adjustment for confounding variables, current smoking men with low serum urate (100 µmol/L) had the highest predicted lung cancer incidence at 125/10,000 PY (95%CI 56-170/10,000 PY) compared with 45/10,000 PY (95%CI 38-47/10,000 PY) for those with the median level (300 µmol/L). Raised measured urate was associated with a lower baseline FEV
conclusionsWe found no evidence that serum urate is a modifiable risk factor for respiratory health or lung cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.