Evidence map›Paper›PMID 34134652›Full record

ArticleBMC pregnancy and childbirth2021

Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports.

Margaret Pikovsky, Min Yi Tan, Amanda Ahmed, Lynne Sykes, Rochan Agha-Jaffar, Christina K H Yu

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Starvation ketosis in a pregnant woman with COVID-19: a case report.Endocrinology, diabetes & metabolism case reports · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Margaret PikovskySt Mary's Hospital, Obstetrics Department, Imperial College NHS Trust, Praed Street, London, W1 2NY, UK.
Min Yi TanSt Mary's Hospital, Obstetrics Department, Imperial College NHS Trust, Praed Street, London, W1 2NY, UK.
Amanda AhmedSt Mary's Hospital, Obstetrics Department, Imperial College NHS Trust, Praed Street, London, W1 2NY, UK.
Lynne SykesSt Mary's Hospital, Obstetrics Department, Imperial College NHS Trust, Praed Street, London, W1 2NY, UK.
Rochan Agha-JaffarEndocrinology Department, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London, W1 2NY, UK.
Christina K H YuSt Mary's Hospital, Obstetrics Department, Imperial College NHS Trust, Praed Street, London, W1 2NY, UK. chrissieyu@chrissieyu.com.
St Mary's Hospital · GBImperial College Healthcare NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEuglycaemic ketoacidosis (EKA) is an infrequent but serious condition which usually follows a period of starvation, severe vomiting or illness in individuals with or without diabetes. Ketoacidosis is associated with materno-fetal morbidity and mortality necessitating prompt diagnosis and management. Physiological increases in insulin resistance render pregnancy a diabetogenic state with increased susceptibility to ketosis. COVID-19 is associated with worse clinical outcomes in patients with diabetes and is an independent risk factor for ketoacidosis in normoglycaemic individuals. CASE PRESENTATIONS: We describe two cases of SARS-CoV-2 positive pregnant women presenting with normoglycaemic metabolic ketoacidosis. Both cases were associated with maternal and fetal compromise, requiring aggressive fluid and insulin resuscitation and early delivery.

conclusionWe discuss possible physiology and propose a management strategy for euglycaemic ketoacidosis in pregnancy.

Indexed as

COVID-19FemaleFluid TherapyHumansInsulin ResistanceKetosisMaternal-Fetal ExchangePregnancyPregnancy ComplicationsSARS-CoV-2StarvationCOVID-19EKAEuglycaemicKetoacidosisPregnancy

Identifiers

PMID34134652
PMCPMC8207493
OpenAlexW3166191126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.