ArticleBMC pediatrics2021
Reintubation rates after extubation to different non-invasive ventilation modes in preterm infants.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Predictors of extubation failure in newborns: a systematic review and meta-analysis.Italian journal of pediatrics · 2023Pooled it
- Automated Detection of Airway Events in Diverse Hospital Settings: Development and Validation of a Scalable System.Journal of medical systems · 2026Article
- Sonographic evaluation of lungs and diaphragm as a predictor for extubation failure in early preterm neonates: a prospective diagnostic accuracy study.European journal of pediatrics · 2025Article
- Guidelines for the use of lung ultrasound to optimise the management of neonatal respiratory distress: international expert consensus.BMC medicine · 2025Article
- Article
- Predictors of successful extubation from volume-targeted ventilation in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Diaphragmatic ultrasound and patent ductus arteriosus in the newborn: A retrospective case series.Frontiers in pediatrics · 2023Article
- Weaning and extubation from neonatal mechanical ventilation: an evidenced-based review.BMC pulmonary medicine · 2022Review
- Duration of postoperative mechanical ventilation in neonates.Translational pediatrics · 2022Article
- Continuing interventions in a quality improvement bundle to reduce bronchopulmonary dysplasia.World journal of pediatrics : WJP · 2022Article
- Positive versus negative pressure during removal of endotracheal-tube on prevention of post-extubation atelectasis in ventilated neonates: A randomized controlled trial.Annals of medicine and surgery (2012) · 2022Article
- Use of NHFOV vs. NIPPV for the respiratory support of preterm newborns after extubation: A meta-analysis.Frontiers in pediatrics · 2022Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRespiratory Distress Syndrome (RDS) is a common cause of neonatal morbidity and mortality in premature newborns. In this study, we aim to compare the reintubation rate in preterm babies with RDS who were extubated to Nasal Continuous Positive Airway Pressure (NCPAP) versus those extubated to Nasal Intermittent Positive Pressure Ventilation (NIPPV).
methodsThis is a retrospective study conducted in the Neonatal Intensive Care Unit (NICU) of Women's Wellness and Research Center (WWRC), Doha, Qatar. The medical files (n = 220) of ventilated preterm infants with gestational age ranging between 28 weeks 0 days and 36 weeks + 6 days gestation and extubated to non-invasive respiratory support (whether NCPAP, NIPPV, or Nasal Cannula) during the period from January 2016 to December 2017 were reviewed.
resultsFrom the study group of 220 babies, n = 97 (44%) babies were extubated to CPAP, n = 77 (35%) were extubated to NIPPV, and n = 46 (21%) babies were extubated to Nasal Cannula (NC). Out of the n = 220 babies, 18 (8.2%) were reintubated within 1 week after extubation. 14 of the 18 (77.8%) were reintubated within 48 h of extubation. Eleven babies needed reintubation after being extubated to NCPAP (11.2%) and seven were reintubated after extubation to NIPPV (9.2%), none of those who were extubated to NC required reintubation (P = 0.203). The reintubation rate was not affected by extubation to any form of non-invasive ventilation (P = 0.625). The mode of ventilation before extubation does not affect the reintubation rate (P = 0.877). The presence of PDA and NEC was strongly associated with reintubation which increased by two and four-folds respectively in those morbidities. There is an increased risk of reintubation with babies suffering from NEC and BPD and this was associated with an increased risk of hospital stay with a P-value ranging (from 0.02-0.003). Using multivariate logistic regression, NEC the NEC (OR = 5.52, 95% CI 1.26, 24.11, P = 0.023) and the vaginal delivery (OR = 0.23, 95% CI 0.07, 0.78, P = 0.018) remained significantly associated with reintubation.
conclusionReintubation rates were less with NIPPV when compared with NCPAP, however, this difference was not statistically significant. This study highlights the need for further research studies with a larger number of neonates in different gestational ages birth weight categories. Ascertaining this information will provide valuable data for the factors that contribute to re-intubation rates and influence the decision-making and management of RDS patients in the future.
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