Evidence map›Paper›PMID 34134058›Full record

ReviewJournal of the neurological sciences2021

Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.

Kiran T Thakur, Arina Tamborska, Greta K Wood, Emily McNeill, David Roh, Imo J Akpan, Eliza C Miller, Alyssa Bautista, Jan Claassen, Carla Y Kim and 11 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of the neurological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. COVID-19 Vaccination and The Eye.American journal of ophthalmology · 2022
    Review
  10. Review
  11. Review
  12. Stroke Associated with COVID-19 Vaccines.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Review
  13. Article
  14. Review
  15. Cerebral venous thrombosis.Arquivos de neuro-psiquiatria · 2022
    Review
  16. Article
  17. Review
  18. Review
  19. Inflammation in Cerebral Venous Thrombosis.Frontiers in immunology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 8 countries.

Kiran T ThakurDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA. Electronic address: ktt2115@cumc.columbia.edu.
Arina TamborskaNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK; Institute of Infection, Veterinary and Ecological Science, University of Liverpool, Liverpool, UK.
Greta K WoodInstitute of Infection, Veterinary and Ecological Science, University of Liverpool, Liverpool, UK.
Emily McNeillDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
David RohDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Imo J AkpanDepartment of Hematology/Oncology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Eliza C MillerDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Alyssa BautistaDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Jan ClaassenDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Carla Y KimDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Alla GuekhtMoscow Research and Clinical Center for Neuropsychiatry & Russian National Research Medical University, Moscow, Russia.
Carlos A PardoDivisions of Neuroimmunology and Neuroinfectious Disorders & Advanced Clinical Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Olajide WilliamsDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
David García-AzorínHeadache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Kameshwar PrasadRajendra Institute of Medical Sciences, Ranchi 834009, Jharkhand, India.
Erich SchmutzhardDepartment of Neurology, Division of Neurocritical Care, Medical University Innsbruck, Innsbruck, Austria.
Benedict D MichaelCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital/Harvard University, Boston, MA, USA.
Sherry H-Y ChouDepartment of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Andrea S WinklerCenter for Global Health, Department of Neurology, Technical University of Munich, Munich, Germany; Centre for Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway.
Tom SolomonNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.
Mitchell S ElkindDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
NewYork–Presbyterian Hospital · USNew York Hospital Queens · USUniversity of Liverpool · GBColumbia University · USHarvard University · USHospital Clínico Universitario de Valladolid · ESInnsbruck Medical University · ATJohns Hopkins University · USMoscow Research and Clinical Center for Neuropsychiatry · RUNational Institute for Health Research · GBRajendra Institute of Medical Sciences · INTechnical University of Munich · DEUniversity of Pittsburgh · US

Funding

Emerging Neuroviruses and Neurological Inflammatory DiseasesR01NS110122 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PARDO-VILLAMIZAR, CARLOS A · 2019 to 2023
$1.7M
Medical Research Council MR/V007181/1Medical Research Council MR/V03605X/1NINDS NIH HHS R01 NS110122
6 · The paper itself

Abstract

backgroundVaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers.

methodsA collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists.

findingsStrategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation.

Indexed as

COVID-19Venous ThrombosisChAdOx1 nCoV-19COVID-19 VaccinesHumansSARS-CoV-2VaccinationChAdOx1 nCoV-19COVID-19 VaccinesCerebral venous thrombosisCOVID-19Vaccination

Identifiers

PMID34134058
PMCPMC8178065
OpenAlexW3170096559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.