ArticleEnvironment international2021
Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants.
Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Prevalence, predictors and adverse perinatal outcomes of placental malaria in sub-Saharan Africa: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2025Pooled it
- Household air pollution exposures over pregnancy and maternal blood pressure trajectories through 8 years postpartum: Evidence from the Ghana Randomized Air Pollution and Health Study (GRAPHS).Environmental research · 2026Trial
- Early life cookstove interventions and children's blood pressure: Evidence from the Ghana randomized air pollution and health study.Environmental research · 2025Trial
- Improved cookstoves enhance household air quality and respiratory health in rural Rwanda.Scientific reports · 2025Trial
- Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial.Environment international · 2025Trial
- Effects of a liquefied petroleum gas stove intervention on stillbirth, congenital anomalies and neonatal mortality: A multi-country household air pollution intervention network trial.Environmental pollution (Barking, Essex : 1987) · 2024Trial
- Household Air Pollution and Child Lung Function: The Ghana Randomized Air Pollution and Health Study.American journal of respiratory and critical care medicine · 2024Trial
- Prenatal Household Air Pollution Exposure and Childhood Blood Pressure in Rural Ghana.Environmental health perspectives · 2024Trial
- Using time-resolved monitor wearing data to study the effect of clean cooking interventions on personal air pollution exposures.Journal of exposure science & environmental epidemiology · 2023Trial
- Antenatal environmental exposure to indoor air pollution and environmental tobacco smoke: association with birth outcomes in an African birth cohort.BMJ open respiratory research · 2026Article
- Prenatal and postnatal household air pollution and longitudinal growth trajectories: results from long-term follow up of the GRAPHS cohort.Environment international · 2026Article
- Household energy use and health in low-income and middle-income countries.The Lancet. Global health · 2026Review
- Prenatal humid heat exposure and cord blood extracellular vesicle microRNA profiles in a Ghanaian Pregnancy Cohort: GRAPHS.Environmental epigenetics · 2026Article
- An exploratory analysis of miRNAs measured in placental tissue and their associations with prenatal exposure to household air pollution.Environmental epigenetics · 2026Article
- Prenatal Harmattan exposure and birth size: identifying sensitive windows in pregnancy.Frontiers in global women's health · 2026Article
- Prenatal exposure to heat and humidity and infant birth size in Ghana.Environmental research · 2025Article
- Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models.Environment international · 2025Article
- Adverse pregnancy outcomes in maternal malarial infection: A systematic review and meta-analysis.New microbes and new infections · 2024Review
- Effect of low-cost kitchen with improved cookstove on birthweight of neonates in Shahjadpur, Bangladesh: a cluster-randomised controlled trial.The Lancet regional health. Southeast Asia · 2024Article
- Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role ofEnvironmental health perspectives · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundLow birth weight and prematurity are important risk factors for death and disability, and may be affected by prenatal exposure to household air pollution (HAP).
methodsWe investigate associations between maternal exposure to carbon monoxide (CO) during pregnancy and birth outcomes (birth weight, birth length, head circumference, gestational age, low birth weight, small for gestational age, and preterm birth) among 1288 live-born infants in the Ghana Randomized Air Pollution and Health Study (GRAPHS). We evaluate whether evidence of malaria during pregnancy, as determined by placental histopathology, modifies these associations.
resultsWe observed effects of CO on birth weight, birth length, and gestational age that were modified by placental malarial status. Among infants from pregnancies without evidence of placental malaria, each 1 ppm increase in CO was associated with reduced birth weight (-53.4 g [95% CI: -84.8, -21.9 g]), birth length (-0.3 cm [-0.6, -0.1 cm]), gestational age (-1.0 days [-1.8, -0.2 days]), and weight-for-age Z score (-0.08 standard deviations [-0.16, -0.01 standard deviations]). These associations were not observed in pregnancies with evidence of placental malaria. Each 1 ppm increase in maternal exposure to CO was associated with elevated odds of low birth weight (LBW, OR 1.14 [0.97, 1.33]) and small for gestational age (SGA, OR 1.14 [0.98, 1.32]) among all infants.
conclusionsEven modest reductions in exposure to HAP among pregnant women could yield substantial public health benefits, underscoring a need for interventions to effectively reduce exposure. Adverse associations with HAP were discernible only among those without evidence of placental malaria, a key driver of impaired fetal growth in this malaria-endemic area.
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