ArticleCell reports2021
Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Sleep deprivation drives hepatic steatosis via sympathetic sprouting-induced ER stress in young male mice.JHEP reports : innovation in hepatology · 2026Article
- Parvalbumin-positive neurons in the medial septum participate in the formation of hippocampal-dependent spatial memory.Nature communications · 2026Article
- Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram.Scientific reports · 2026Article
- Self-perceived life course sleep duration trajectories and risk and age at onset of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies.Aging and disease · 2025Review
- Preoperative Sleep Deprivation Exacerbates Anesthesia/Surgery-induced Abnormal GABAergic Neurotransmission and Neuronal Damage in the Hippocampus in Aged Mice.Molecular neurobiology · 2025Article
- Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation.Nature communications · 2024Article
- Article
- Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety.JCI insight · 2024Article
- Molecular mechanisms of aging and anti-aging strategies.Cell communication and signaling : CCS · 2024Review
- Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1.Neurochemical research · 2024Article
- Mystery of the memory engram: History, current knowledge, and unanswered questions.Neuroscience and biobehavioral reviews · 2024Review
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Anesthetic spindles serve as EEG markers of the depth variations in anesthesia induced by multifarious general anesthetics in mouse experiments.Frontiers in pharmacology · 2024Article
- Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Frontiers in cellular neuroscience · 2023Review
- Regulation of dendritic spines in the amygdala following sleep deprivation.Frontiers in sleep · 2023Article
- Neural consequences of chronic sleep disruption.Trends in neurosciences · 2022Review
- Navigable Space and Traversable Edges Differentially Influence Reorientation in Sighted and Blind Mice.Psychological science · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) "context" cells, which remain stable throughout training and testing, and (2) "object configuration" cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.