ArticleCell reports2021
Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
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- Microendoscopic calcium imaging in motor cortices of macaques during rest and movement.iScience · 2025Article
- CalliCog is an open-source cognitive neuroscience toolkit for freely behaving nonhuman primates.Cell reports methods · 2025Article
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- ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex.Nature communications · 2024Article
- Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning.Nature communications · 2024Article
- The selfish network: how the brain preserves behavioral function through shifts in neuronal network state.Trends in neurosciences · 2024Review
- Low frequency independent components: Internal neuromarkers linking cortical LFPs to behavior.iScience · 2024Article
- Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.Nature communications · 2024Article
- A Neural Implant Design Toolbox for Nonhuman Primates.Journal of visualized experiments : JoVE · 2024Article
- Calcium imaging: a technique to monitor calcium dynamics in biological systems.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Emergence of task-related spatiotemporal population dynamics in transplanted neurons.Nature communications · 2023Article
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- 2-Photon imaging of fluorescent proteins in living swine.Scientific reports · 2023Article
- Intravenous functional gene transfer throughout the brain of non-human primates using AAV.Research square · 2023Article
- Visualizing advances in the future of primate neuroscience research.Current research in neurobiology · 2023Review
- Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.Cell reports methods · 2022Article
- Review
- Large-volume and deep brain imaging in rabbits and monkeys using COMPACT two-photon microscopy.Scientific reports · 2022Article
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8 authors at 3 institutions in 1 country.
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Abstract
Microendoscopic calcium imaging with one-photon miniature microscopes enables unprecedented readout of neural circuit dynamics during active behavior in rodents. In this study, we describe successful application of this technology in the rhesus macaque, demonstrating plug-and-play, head-mounted recordings of cellular-resolution calcium dynamics from large populations of neurons simultaneously in bilateral dorsal premotor cortices during performance of a naturalistic motor reach task. Imaging is stable over several months, allowing us to longitudinally track individual neurons and monitor their relationship to motor behavior over time. We observe neuronal calcium dynamics selective for reach direction, which we could use to decode the animal's trial-by-trial motor behavior. This work establishes head-mounted microendoscopic calcium imaging in macaques as a powerful approach for studying the neural circuit mechanisms underlying complex and clinically relevant behaviors, and it promises to greatly advance our understanding of human brain function, as well as its dysfunction in neurological disease.
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