ArticleCell reports2021
Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesis.Neurobiology of disease · 2026Article
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
- Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.Disease models & mechanisms · 2026Article
- MeCP2 regulates telencephalic development in human cerebral organoids.Cell reports · 2025Article
- Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication.Nature communications · 2025Article
- Interneuron Diversity: How Form Becomes Function.Cold Spring Harbor perspectives in biology · 2025Review
- Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets.Journal of anatomy · 2025Article
- PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Nature neuroscience · 2025Article
- Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies.Biomolecules · 2025Review
- Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.Science (New York, N.Y.) · 2024Article
- CUT homeobox genes: transcriptional regulation of neuronal specification and beyond.Frontiers in cellular neuroscience · 2023Review
- Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium.Frontiers in molecular neuroscience · 2023Article
- Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.Nature communications · 2022Article
- Interferon-γ augments GABA release in the developing neocortexFrontiers in cellular neuroscience · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Cortical GABAergic interneurons are generated in large numbers in the ganglionic eminences and migrate into the cerebral cortex during embryogenesis. At early postnatal stages, during neuronal circuit maturation, autonomous and activity-dependent mechanisms operate within the cortex to adjust cell numbers by eliminating naturally occurring neuron excess. Here, we show that when cortical interneurons are generated in aberrantly high numbers-due to a defect in precursor cell proliferation during embryogenesis-extra parvalbumin interneurons persist in the postnatal mouse cortex during critical periods of cortical network maturation. Even though cell numbers are subsequently normalized, behavioral abnormalities remain in adulthood. This suggests that timely clearance of excess cortical interneurons is critical for correct functional maturation of circuits that drive adult behavior.
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