Evidence map›Paper›PMID 34133900›Full record

ArticleJournal of virology2021

TLR1/2 Agonist Enhances Reversal of HIV-1 Latency and Promotes NK Cell-Induced Suppression of HIV-1-Infected Autologous CD4

Siqin Duan, Xinfeng Xu, Jinshen Wang, Liwen Huang, Jie Peng, Tao Yu, Yang Zhou, Kui Cheng, Shuwen Liu

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
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  7. Article
  8. Review
  9. Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic Approach.International journal of molecular sciences · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Siqin DuanGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Xinfeng XuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jinshen WangGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Liwen HuangGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jie PengDivision of Infectious Diseases, Nanfang Hospitalgrid.416466.7, Southern Medical University, Guangzhou, China.
Tao YuDivision of Infectious Diseases, Nanfang Hospitalgrid.416466.7, Southern Medical University, Guangzhou, China.
Yang ZhouDivision of Infectious Diseases, Third People's Hospital of Shenzhen, Shenzhen, China.
Kui ChengGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Shuwen LiuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Southern Medical University · CNNanfang Hospital · CNShenzhen Third People’s Hospital · CN

Funding

MOST | National Science and Technology Infrastructure Program (National Key Science Projects Program) 2018ZX10301101National Natural Science Foundation of China (NSFC) 81773787People's Government of Guangdong Province | National Natural Science Foundation of China-Guangdong Joint Fund (NSFC-Guangdong Joint Fund) 2018030312010
6 · The paper itself

Abstract

The complete eradication of human immunodeficiency virus type 1 (HIV-1) is blocked by latent reservoirs in CD4

Indexed as

Virus LatencyAnti-Retroviral AgentsCD4-Positive T-LymphocytesHIV-1HIV InfectionsHumansImidazolesKiller Cells, NaturalLeukocytes, MononuclearLymphocyte ActivationPhenolsSmall Molecule LibrariesToll-Like Receptor 1Toll-Like Receptor 2Viral LoadVirus ActivationAnti-Retroviral AgentsImidazolesPhenolsSmall Molecule LibrariesSMU-Z1TLR1 protein, humanTLR2 protein, humanToll-Like Receptor 1Toll-Like Receptor 2HIV-1 reservoirslatency-reversing agentsNK cellsshock and killTLR2

Identifiers

PMID34133900
PMCPMC8354220
OpenAlexW3171542315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.