ArticleArquivos brasileiros de cardiologia2021
Influence of Consumption of Orange Juice (Citrus Sinensis) on Cardiac Remodeling of Rats Submitted to Myocardial Infarction.
Article in Arquivos brasileiros de cardiologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach.Metabolites · 2025Article
- Research progress on the natural products in the intervention of myocardial infarction.Frontiers in pharmacology · 2024Review
- Effects of Pera Orange Juice and Moro Orange Juice in Healthy Rats: A Metabolomic Approach.Metabolites · 2023Article
- Oxidative Stress as a Therapeutic Target of Cardiac Remodeling.Antioxidants (Basel, Switzerland) · 2022Review
- Role of Nutrients and Foods in Attenuation of Cardiac Remodeling through Oxidative Stress Pathways.Antioxidants (Basel, Switzerland) · 2022Review
- The Year in Basic Research 2021: the Search for Translational Models.Arquivos brasileiros de cardiologia · 2022Article
- Pterostilbene after Acute Myocardial Infarction: Effect on Heart and Lung Tissues.Arquivos brasileiros de cardiologia · 2022Article
- Article
- Antioxidant and Anti-Inflammatory Effects of Orange Juice.Arquivos brasileiros de cardiologia · 2021Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOrange juice (OJ) is rich in polyphenols with anti-inflammatory and antioxidant properties. After myocardial infarction (MI), complex changes occur in cardiac structure and function, which is known as cardiac remodeling (CR). Oxidative stress and inflammation can modulate this process. We hypothesized that the consumption of OJ attenuates the CR after MI.
objectivesTo evaluate the influence of OJ on CR after MI by analysis of functional, morphological, oxidative stress, inflammation, and energy metabolism variables.
methodsA total of 242 male rats weighing 200-250 g were submitted to a surgical procedure (coronary artery ligation or simulated surgery). Seven days after surgery, survivors were assigned to one of the four groups 1) SM, sham animals with water and maltodextrin (n= 20); 2) SOJ, sham animals with OJ (n= 20); 3) IM, infarcted animals with water and maltodextrin (n= 40); and 4) IOJ, infarcted animals with OJ (n = 40). Statistical analysis was performed by the two-way ANOVA supplemented by Holm-Sidak. Results are presented as mean ± standard deviation, the level of significance adopted was 5%.
resultsAfter 3 months, MI led to left ventricular (LV) hypertrophy, with systolic and diastolic dysfunction, and increased oxidative stress and inflammatory mediators. OJ intake reduced LV cavity and improved systolic and diastolic function. The OJ animals presented lower activity of glutathione peroxidase and higher expression of heme-oxygenase-1 (HO-1).
conclusionOJ attenuated CR in infarcted rats and HO-1 may be play an important role in this process.
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