Evidence map›Paper›PMID 34133284›Full record

ArticleIEEE/ACM transactions on computational biology and bioinformatics

SAU-Net: A Unified Network for Cell Counting in 2D and 3D Microscopy Images.

Yue Guo, Oleh Krupa, Jason Stein, Guorong Wu, Ashok Krishnamurthy

Open access · greenAbstract read
In one paragraph

Article in IEEE/ACM transactions on computational biology and bioinformatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. CsDETC: detection and counting of small targetFrontiers in cellular and infection microbiology · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yue Guo
Oleh Krupa
Jason Stein
Guorong Wu
Ashok Krishnamurthy
University of North Carolina at Chapel Hill · US

Funding

A Scalable Platform for Exploring and Analyzing Whole Brain Tissue Cleared ImagesR01NS110791 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, GUORONG · 2019 to 2023
$1.9M
NINDS NIH HHS R01 NS110791
6 · The paper itself

Abstract

Image-based cell counting is a fundamental yet challenging task with wide applications in biological research. In this paper, we propose a novel unified deep network framework designed to solve this problem for various cell types in both 2D and 3D images. Specifically, we first propose SAU-Net for cell counting by extending the segmentation network U-Net with a Self-Attention module. Second, we design an extension of Batch Normalization (BN) to facilitate the training process for small datasets. In addition, a new 3D benchmark dataset based on the existing mouse blastocyst (MBC) dataset is developed and released to the community. Our SAU-Net achieves state-of-the-art results on four benchmark 2D datasets - synthetic fluorescence microscopy (VGG) dataset, Modified Bone Marrow (MBM) dataset, human subcutaneous adipose tissue (ADI) dataset, and Dublin Cell Counting (DCC) dataset, and the new 3D dataset, MBC. The BN extension is validated using extensive experiments on the 2D datasets, since GPU memory constraints preclude use of 3D datasets. The source code is available at https://github.com/mzlr/sau-net.

Indexed as

Imaging, Three-DimensionalMicroscopyAnimalsAttentionHumansImage Processing, Computer-AssistedMice

Identifiers

PMID34133284
PMCPMC8924707
OpenAlexW3170293501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.