Evidence map›Paper›PMID 34133239›Full record

ReviewAmerican journal of physiology. Cell physiology2021

Emerging cellular-based therapies in carbon monoxide poisoning.

David H Jang, Sarah Piel, John C Greenwood, Johannes K Ehinger, Todd J Kilbaugh

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Blood Cells as a Cellular Biomarker for Mitochondrial Function in a Experimental Model of Acute Carbon Monoxide Poisoning with Treatment.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025
    Article
  3. Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Effect of hyperbaric oxygen on symptoms of dementia in patients with delayed encephalopathy after acute carbon monoxide poisoning.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

David H JangDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-1213-6971
Sarah PielDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Resuscitation Science Center CHOP Research Institute, Philadelphia, Pennsylvania.
John C GreenwoodDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Johannes K EhingerMitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Resuscitation Science Center CHOP Research Institute, Philadelphia, Pennsylvania.
Children's Hospital of Philadelphia · USLund University · SEUniversity of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeR01HL141386 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KILBAUGH, TODD JUSTEN · 2019 to 2023
$4.4M
The Use of Blood Cells as a Biomarker in a Porcine Model of CO Poisoning with Evaluation of an Engineered Succinate-ProdrugR56HL158696 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JANG, DAVID H · 2021 to 2021
$697k
Abnormal Mitochondrial Bioenergetic and Motility Signatures in Human Blood Cells as Indices of Acute Poisoning in PatientsK08HL136858 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JANG, DAVID H · 2018 to 2021
$675k
Mitochondrial-Directed Therapy in Carbon Monoxide PoisoningR21ES031243 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI JANG, DAVID H · 2020 to 2021
$465k
Development of a Porcine Model of Carbon Monoxide Poisoning to Evaluate Cardiac and Mitochondrial DysfunctionR03HL154232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JANG, DAVID H · 2020 to 2021
$150k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K08HL136858HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL141386HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R03HL154232HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) R21ES031243NHLBI NIH HHS K08 HL136858NHLBI NIH HHS R01 HL141386NHLBI NIH HHS R03 HL154232NHLBI NIH HHS R56 HL158696NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R21 ES031243
6 · The paper itself

Abstract

Carbon monoxide (CO) is an odorless and colorless gas with multiple sources that include engine exhaust, faulty furnaces, and other sources of incomplete combustion of carbon compounds such as house fires. The most serious complications for survivors of consequential CO exposure are persistent neurological sequelae occurring in up to 50% of patients. CO inhibits mitochondrial respiration by specifically binding to the heme a

Indexed as

Cell- and Tissue-Based TherapyAnimalsCarbon MonoxideCarbon Monoxide PoisoningHumansMitochondriaProdrugsSuccinic AcidCarbon MonoxideProdrugsSuccinic Acidcarbon monoxidecellular therapiesmitochondriarespirationsuccinate prodrug

Identifiers

PMID34133239
PMCPMC8424679
OpenAlexW3172736608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.