Evidence map›Paper›PMID 34133231›Full record

ArticleJournal of empirical research on human research ethics : JERHRE2021

Perceived Social Influences on Women's Decisions to use Medications not Studied in Pregnancy. A Qualitative Ethical Analysis of Preexposure Prophylaxis Implementation Research in Kenya.

Kenneth Ngure, Susan B Trinidad, Kristin Beima-Sofie, John Kinuthia, Daniel Matemo, Grace Kimemia, Anne Njoroge, Lillian Achiro, Jillian Pintye, Nelly R Mugo and 5 more

Abstract read
In one paragraph

Article in Journal of empirical research on human research ethics : JERHRE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kenneth NgureDepartment of Community Health, 118985Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.ORCID 0000-0002-8062-0933
Susan B TrinidadDepartment of Bioethics and Humanities, University of Washington, Seattle, WA, USA.
Kristin Beima-SofieDepartment of Global Health, University of Washington, Seattle, WA, USA.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, WA, USA.
Daniel MatemoDepartment of Research and Programs, 285569Kenyatta National Hospital, Nairobi, Kenya.
Grace KimemiaPopulation Dynamic and Reproductive Health, 107883African Population and Health Research Center, Nairobi, Kenya.
Anne NjorogeDepartment of Global Health, University of Washington, Seattle, WA, USA.
Lillian AchiroCenter for Microbiology Research, 118982Kenya Medical Research Institute Nairobi, Kenya.
Jillian PintyeDepartment of Global Health, University of Washington, Seattle, WA, USA.
Nelly R MugoDepartment of Global Health, University of Washington, Seattle, WA, USA.
Elizabeth A BukusiDepartment of Global Health, University of Washington, Seattle, WA, USA.
Jared M BaetenDepartment of Global Health, University of Washington, Seattle, WA, USA.
Renee HeffronDepartment of Global Health, University of Washington, Seattle, WA, USA.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, WA, USA.
Maureen C KelleyWellcome Centre for Ethics & Humanities and Ethox Centre, Nuffield Department of Population Health, 6396University of Oxford, Oxford, UK.

Funding

Optimizing Antiretroviral-Based HIV Prevention for HIV Serodiscordant CouplesR01MH095507 · NIMH · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2011 to 2020
$6.1M
Optimizing Delivery of ART/PrEP for HIV Prevention through Qualitative ResearchR01MH101027 · NIMH · HARVARD MEDICAL SCHOOL · PI KATABIRA, ELLY T, WARE, NORMA C · 2013 to 2016
$2.2M
Antiretroviral periconception HIV prevention for HIV discordant couplesR00HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2015 to 2017
$742k
Development of Real-Time Antiretroviral Therapy Adherence Intervention in UgandaR34MH100940 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2013 to 2015
$593k
PrEP EXPOSURE DURING HIV-1 INFECTION AND THE RISK OF LOW-FREQUENCY ARV RESISTANCER21AI104449 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEHMAN, DARA ANN · 2013 to 2014
$496k
Antiretroviral periconception HIV prevention for HIV discordant couplesK99HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2013 to 2014
$208k
Medical Research Council MC_PC_16025NIAID NIH HHS R21 AI104449NICHD NIH HHS K99 HD076679NICHD NIH HHS R00 HD076679NIMH NIH HHS R01 MH095507NIMH NIH HHS R01 MH101027NIMH NIH HHS R34 MH100940Wellcome TrustWellcome Trust 200344/Z/15/ZWellcome Trust 206536/Z/17/Z
6 · The paper itself

Abstract

Implementation research ethics can be particularly challenging when pregnant women have been excluded from earlier clinical stages of research given greater uncertainty about safety and efficacy in pregnancy. The evaluation of human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) during pregnancy offered an opportunity to understand important ethical considerations and social influences shaping women's decisions to participate in the evaluation of PrEP and investigational drugs during pregnancy. We conducted interviews with women (

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAdolescentEthical AnalysisFemaleHumansKenyaMalePregnancyQualitative ResearchAnti-HIV Agentsconsenthuman immunodeficiency virus preventionpartnerspreexposure prophylaxispregnancyrelational autonomyresearch ethicssocial influences

Identifiers

PMID34133231
PMCPMC8261769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.