Evidence map›Paper›PMID 34133216›Full record

ArticleMolecular biology of the cell2021

Cross-talk-dependent cortical patterning of Rho GTPases during cell repair.

Alison Moe, William Holmes, Adriana E Golding, Jessica Zola, Zachary T Swider, Leah Edelstein-Keshet, William Bement

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alison MoeProgram in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706.
William HolmesDepartment of Physics and Astronomy, Vanderbilt University, Nashville, TN 37212.
Adriana E GoldingProgram in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706.
Jessica ZolaCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI 53706.
Zachary T SwiderProgram in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706.
Leah Edelstein-KeshetDepartment of Mathematics, University of British Columbia, Vancouver, BC V6T 1Z2, Canada.
William BementProgram in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706.
University of Wisconsin–Madison · USUniversity of British Columbia · CAVanderbilt University · US

Funding

Transient cytoskeletal arraysR01GM052932 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BEMENT, WILLIAM · 1997 to 2023
$7.2M
NIGMS NIH HHS R01 GM052932
6 · The paper itself

Abstract

Rho GTPases such as Rho, Rac, and Cdc42 are important regulators of the cortical cytoskeleton in processes including cell division, locomotion, and repair. In these processes, Rho GTPases assume characteristic patterns wherein the active GTPases occupy mutually exclusive "zones" in the cell cortex. During cell wound repair, for example, a Rho zone encircles the wound edge and is in turn encircled by a Cdc42 zone. Here we evaluated the contributions of cross-talk between Rho and Cdc42 to the patterning of their respective zones in wounded

Indexed as

Signal TransductionAnimalsCytoskeletonModels, BiologicalMonomeric GTP-Binding ProteinsOocytesrho GTP-Binding ProteinsXenopus laevisXenopus ProteinsCdc42 protein, XenopusMonomeric GTP-Binding Proteinsrho GTP-Binding ProteinsXenopus Proteins

Identifiers

PMID34133216
PMCPMC8351735
OpenAlexW3172260493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.