Evidence map›Paper›PMID 34133149›Full record

ArticleEnvironmental science & technology2021

Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate.

Jiajun Han, Jesse Fu, Jianxian Sun, David Ross Hall, Diwen Yang, Donovan Blatz, Keith Houck, Carla Ng, Jon Doering, Carlie LaLone and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Functional thermodynamics govern the ligand binding to human cytosolic transport proteins.Protein science : a publication of the Protein Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jiajun HanDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Jesse FuDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Jianxian SunDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
David Ross HallDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Diwen YangDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Donovan BlatzU.S. Environmental Protection Agency, Oak Ridge Institute for Science and Education, Duluth, Minnesota 55804, United States.
Keith HouckCenter for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.ORCID 0000-0002-0055-2249
Carla NgDepartment of Civil & Environmental Engineering and Department of Environmental and Occupational Health, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0001-5521-7862
Jon DoeringNational Research Council, Duluth, Minnesota 55804, United States.ORCID 0000-0001-6866-6456
Carlie LaLoneCenter for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Duluth, Minnesota 55804, United States.ORCID 0000-0003-3174-1314
Hui PengDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.ORCID 0000-0002-2777-0588
University of Toronto · CAEnvironmental Protection Agency · USNational Academies of Sciences, Engineering, and Medicine · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluating interspecies toxicity variation is a long-standing challenge for chemical hazard assessment. This study developed a quantitative interspecies thermal shift assay (QITSA) for

Indexed as

FluorocarbonsProteomicsAlkanesulfonic AcidsAnimalsFatty Acid-Binding ProteinsFatty AcidsHumansLiverMiceRatsSpecies SpecificityZebrafishAlkanesulfonic AcidsFatty Acid-Binding ProteinsFatty AcidsFluorocarbonsperfluorooctane sulfonic aciddissociation constantinterspecies toxicitiesprotein foldingproteomicsthermal stability

Identifiers

PMID34133149
PMCPMC9189739
OpenAlexW3167708514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.