Evidence map›Paper›PMID 34133018›Full record

ArticlePharmacological reports : PR2021

Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept.

Agata Szymaszkiewicz, Mikołaj Świerczyński, Marcin Talar, Prabhakar Reddy Polepally, Jordan K Zjawiony, Jakub Fichna, Marta Zielińska

Open access · hybridAbstract read
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In one paragraph

Article in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Agata SzymaszkiewiczDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Mikołaj ŚwierczyńskiDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Marcin TalarDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Prabhakar Reddy PolepallyDepartment of Biomolecular Sciences and Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS, USA.
Jordan K ZjawionyDepartment of Biomolecular Sciences and Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS, USA.
Jakub FichnaDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Marta ZielińskaDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland. marta.zielinska@umed.lodz.pl.ORCID http://orcid.org/0000-0003-0418-1948
Medical University of Lodz · PLUniversity of Mississippi · US

Funding

Uniwersytet Medyczny w Lodzi #503/1-156-04/503-11-001-19-00Uniwersytet Medyczny w Lodzi 63/2014-2015
6 · The paper itself

Abstract

introductionTolerance (TOL) and physical dependence (PD) constitute important limitations of opioid therapy. The aim of our study was to validate research tools to investigate TOL and PD and to characterize the interactions between opioid (OR) and cannabinoid (CB) receptors in these processes in the GI tract.

methodsTOL was assessed through the comparison of morphine ability to inhibit electrically evoked smooth muscles contractility in the mouse ileum that was previously incubated with/without morphine for 1 h. To evaluate the PD, the ileum was incubated with morphine for 10 min, then challenged with naloxone to induce withdrawal response (WR). The OR/CB interactions were evaluated using mixed agonist (PR-38) and AM-251 (CB1 antagonist).

resultsThe inhibitory effect of morphine on ileal contractions was weaker in tissue incubated with this opioid than in tissue incubated without opioid. The opposite was noted for PR-38. In tissues exposed to morphine, but not to PR-38, naloxone induced a WR. The blockage of CB1 receptors with AM-251 before the addition of PR-38 resulted in a naloxone-induced WR.

conclusionThe co-activation of OR and CB reduced development of TOL and PD to opioids in the mouse GI tract and mixed OR/CB agonists are promising alternative to currently used opioid drugs.

Indexed as

Analgesics, OpioidAnimalsCannabinoidsDiterpenes, ClerodaneDrug ToleranceIleumMaleMiceMice, Inbred BALB CMorphineMuscle, SmoothNaloxonePiperidinesPyrazolesReceptors, CannabinoidSubstance Withdrawal Syndrome2-O-cinnamoylsalvinorin BAM 251Analgesics, OpioidCannabinoidsDiterpenes, ClerodaneMorphineNaloxonePiperidinesPyrazolesReceptors, CannabinoidCo-activationCross-talkOpioidsPhysical dependencePR-38Tolerance

Identifiers

PMID34133018
PMCPMC8413198
OpenAlexW3172214582

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.