Evidence map›Paper›PMID 34132971›Full record

Observational studyInternational urology and nephrology2022

Evaluation of central venous catheter and other risk factors for mortality in chronic hemodialysis patients with COVID-19 in Brazil.

Jocemir Ronaldo Lugon, Precil Diego Miranda de Menezes Neves, Andrea Pio-Abreu, Marcelo Mazza do Nascimento, Ricardo Sesso, COVID-19 HD-Brazil Investigators

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. The association between stroke and COVID-19-related mortality: a systematic review and meta-analysis based on adjusted effect estimates.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  17. Brazilian Dialysis Survey 2021.Jornal brasileiro de nefrologia
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  18. Brazilian Dialysis Survey 2020.Jornal brasileiro de nefrologia
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jocemir Ronaldo LugonUniversidade Federal Fluminense, Niterói, RJ, Brazil.ORCID http://orcid.org/0000-0001-6791-3910
Precil Diego Miranda de Menezes NevesHospital das Clínicas da Faculdade de Medicina da USP, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-1089-6763
Andrea Pio-AbreuHospital das Clínicas da Faculdade de Medicina da USP, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-5118-7990
Marcelo Mazza do NascimentoUniversidade Federal Do Paraná, Curitiba, PR, Brazil.ORCID http://orcid.org/0000-0003-2876-2923
Ricardo SessoDivision of Nephrology, Escola Paulista de Medicina, Federal University of São Paulo, Rua Botucatu 740, São Paulo, SP, 04023-900, Brazil. rsesso@unifesp.br.ORCID http://orcid.org/0000-0002-1062-0073
COVID-19 HD-Brazil Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHemodialysis patients with COVID-19 are at increased risk of death. We aimed to describe the characteristics of a cohort of Brazilian hemodialysis patients with COVID-19 and assess their mortality rate and risk factors for death.

methodsRetrospective cohort study of 741 Brazilian hemodialysis patients with confirmed COVID-19 from Feb-Dec/2020, of 52 dialysis centers of the country. We analyzed comorbid conditions, sociodemographic factors, and dialysis-related parameters. To detect risk factors for mortality in hemodialysis patients, we performed multivariable Cox proportional hazard regression analysis. Survival was analyzed by Kaplan-Meier.

resultsFrom 9877 hemodialysis patients, 741 were diagnosed with COVID-19. Mean age was 57 ± 16 years, 61% were male, and 51% white. The most frequent symptoms were fever (54.1%), cough (50.9%), and dyspnea (37.2%); 14.2% were asymptomatic. There were 139 deaths (18.8%), with 66% within the disease's first 15 days. 333 patients (44.9%) required hospitalization, and 211 (28.5%) were admitted to an intensive care unit. The cumulative probability of survival at 90 days of diagnosis was 79% (95% CI 76-82%). In the fully adjusted multivariate model, the risk factors significantly associated with death were diabetes mellitus (HR 1.52, 95% CI 1.05-2.19, P = 0.026), use of a central venous catheter (CVC) (HR 1.79, 95% CI 1.22-2.64, P = 0.003), age (HR 1.03, 95% CI 1.01-1.04, P < 0.001), and origin from the North vs. Southeast region (HR 2.60, 95% CI 1.01-6.68, P = 0.047).

conclusionsHemodialysis patients using a CVC as the vascular access, aside from diabetic and elderly ones, should be closely monitored due to their high risk of death in the course of the COVID-19.

Indexed as

BrazilCatheter-Related InfectionsCentral Venous CathetersComorbidityCOVID-19FemaleFollow-Up StudiesHumansIncidenceKidney Failure, ChronicMaleMiddle AgedRenal DialysisRetrospective StudiesSARS-CoV-2Survival RateBrazilCentral venous catheterCOVID-19HemodialysisMortalityRisk factors

Identifiers

PMID34132971
PMCPMC8207494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.