Evidence map›Paper›PMID 34132584›Full record

ArticleJournal of clinical microbiology2021

The Usefulness of Two CXCL13 Assays on Cerebrospinal Fluid for the Diagnosis of Lyme Neuroborreliosis: a Retrospective Study in a Routine Clinical Setting.

Tamara van Gorkom, Gijs H J van Arkel, Michiel Heron, Willem Voet, Steven F T Thijsen, Kristin Kremer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tamara van GorkomDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, The Netherlands.
Gijs H J van ArkelDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, The Netherlands.
Michiel HeronDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, The Netherlands.
Willem VoetDepartment of Neurology, Diakonessenhuis Hospital, Utrecht, The Netherlands.
Steven F T ThijsenDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, The Netherlands.
Kristin KremerCentre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Diakonessenhuis hospital · NLNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have shown elevated levels of the B-cell chemokine (C-X-C motif) ligand 13 (CXCL13) in the cerebrospinal fluid (CSF) of patients with early Lyme neuroborreliosis (LNB). In this retrospective study, we evaluated the diagnostic performance of the Quantikine CXCL13 enzyme-linked immunosorbent assay (ELISA) (R&D Systems, Inc., MN, USA) and the

Indexed as

Lyme NeuroborreliosisChemokine CXCL13Enzyme-Linked Immunosorbent AssayHumansImmunologic TestsRetrospective StudiesROC CurveChemokine CXCL13CXCL13 protein, humanblood-CSF barrier functionalityBorreliacerebrospinal fluidCXCL13intrathecal antibody synthesisLyme neuroborreliosisReibergram

Identifiers

PMID34132584
PMCPMC8373006
OpenAlexW3172566692

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.