Evidence map›Paper›PMID 34132500›Full record

ArticleBrain and behavior2021

Brain-derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease.

E Chang, Jiongmei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  5. Disruption of BDNF signalling in neuropathologies.Biochemical Society transactions · 2026
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  16. Neuroprotective effect of hyperoside in MPPMetabolic brain disease · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

E ChangDepartment of Rehabilitation Medicine, Cangzhou Central Hospital, Cangzhou, Hebei, China.ORCID 0000-0003-3887-8997
Jiongmei WangDepartment of Rehabilitation Medicine, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is one of the most common neurodegenerative disorders that seriously impair the life quality and survival of patients. Herein, we aim to investigate the neuroprotective roles of brain-derived neurotrophic factor (BDNF) in PD mice and reveal the underlying mechanisms. BDNF overexpression was achieved via the injection of adeno-associated viruses (AAV) with BDNF gene.

methodsPD mouse model was established by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. Tests of rotarod, pole, open field, and novel object recognition were conducted to evaluate the motor and cognitive functions of treated mice.

resultsMitochondrial impairment, mitochondrial respiratory chain enzymes, and tyrosine hydroxylase (TH)-positive dopaminergic neurons were detected to uncover the molecular mechanism. BDNF overexpression attenuated motor deficits and cognitive impairment in MPTP-induced PD mice. Mechanistically, BDNF mitigated mitochondrial impairment increased the activity of respiratory chain Complex I and Ⅱ+III, and finally alleviated TH-positive dopaminergic neuron loss in MPTP-induced PD mice.

conclusionThis study highlights the potential of BDNF as a therapeutic candidate for the treatment of mitochondrial impairment-associated neurodegenerative diseases.

Indexed as

Cognitive DysfunctionNeuroprotective AgentsParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain-Derived Neurotrophic FactorDisease Models, AnimalDopaminergic NeuronsHumansMiceMice, Inbred C57BLSubstantia Nigra1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineBrain-Derived Neurotrophic FactorNeuroprotective AgentsBDNFbehaviordopaminergic neuronmitochondriaParkinson's disease

Identifiers

PMID34132500
PMCPMC8413743
OpenAlexW3166638042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.