ArticleMolecular systems biology2021
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Newly found functions and regulatory networks of WOX family: what else does the WOX say?Planta · 2026Review
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- Brassinosteroids control cell proliferation in the lateral root cap of the Arabidopsis root.EMBO reports · 2026Article
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- The LFR-SWI/SNF complex: A chromatin wrench safeguarding cellular quiescence in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Progress and Prospects in FRET for the Investigation of Protein-Protein Interactions.Biosensors · 2025Review
- Out of the Niche: A Bird's-Eye View of the Molecular Networks Controlling Root Stem Cells.Plants (Basel, Switzerland) · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- A coherent feed-forward loop in the Arabidopsis root stem cell organizer regulates auxin biosynthesis and columella stem cell maintenance.Nature plants · 2024Article
- Stem cell quiescence and dormancy in plant meristems.Journal of experimental botany · 2024Review
- Single-cell network analysis reveals gene expression programs for Arabidopsis root development and metabolism.Plant communications · 2024Article
- Brassinosteroid gene regulatory networks at cellular resolution in theScience (New York, N.Y.) · 2023Article
- A blast from the past: Understanding stem cell specification in plant roots using laser ablation.Quantitative plant biology · 2023Article
- A mutation in THREONINE SYNTHASE 1 uncouples proliferation and transition domains of the root apical meristem: experimental evidence and in silico proposed mechanism.Development (Cambridge, England) · 2022Article
- MYB Transcription Factors Becoming Mainstream in Plant Roots.International journal of molecular sciences · 2022Review
- BRAVO self-confined expression through WOX5 in the Arabidopsis root stem-cell niche.Development (Cambridge, England) · 2022Article
- A Journey to the Core of the Plant Cell Cycle.International journal of molecular sciences · 2022Review
- Visualization of in vivo protein-protein interactions in plants.Journal of experimental botany · 2022Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding stem cell regulatory circuits is the next challenge in plant biology, as these cells are essential for tissue growth and organ regeneration in response to stress. In the Arabidopsis primary root apex, stem cell-specific transcription factors BRAVO and WOX5 co-localize in the quiescent centre (QC) cells, where they commonly repress cell division so that these cells can act as a reservoir to replenish surrounding stem cells, yet their molecular connection remains unknown. Genetic and biochemical analysis indicates that BRAVO and WOX5 form a transcription factor complex that modulates gene expression in the QC cells to preserve overall root growth and architecture. Furthermore, by using mathematical modelling we establish that BRAVO uses the WOX5/BRAVO complex to promote WOX5 activity in the stem cells. Our results unveil the importance of transcriptional regulatory circuits in plant stem cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.