Evidence map›Paper›PMID 34132470›Full record

ArticleJournal of the International AIDS Society2021

Evidence of an untamed HIV epidemic among MSM and TGW in Rio de Janeiro, Brazil: a 2018 to 2020 cross-sectional study using recent infection testing.

Sylvia Lm Teixeira, Cristina M Jalil, Emilia M Jalil, Sandro C Nazer, Simone da Costa Cruz Silva, Valdilea G Veloso, Paula M Luz, Beatriz Grinsztejn

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sylvia Lm TeixeiraOswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Cristina M JalilNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Emilia M JalilNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0001-6017-5660
Sandro C NazerNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Simone da Costa Cruz SilvaNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Valdilea G VelosoNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Paula M LuzNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0001-9746-719X
Beatriz GrinsztejnNational Institute of Infectious Diseases Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0003-3692-5155
Instituto Evandro Chagas · BRFundação Oswaldo Cruz · BR

Funding

The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)UM1AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI BEATRIZ GRINSZTEJN · 2012 to 2026
$26.3M
The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)U01AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI GRINSZTEJN, BEATRIZ · 2008 to 2011
$14.0M
NIAID NIH HHS U01 AI069476NIAID NIH HHS UM1 AI069476
6 · The paper itself

Abstract

introductionMonitoring the HIV epidemic and identifying populations among whom HIV is spreading is critical. We aimed to provide an estimate of the annualized HIV incidence rate using recency testing among cisgender men who have sex with men (MSM) and transgender women (TGW) at a reference centre in Rio de Janeiro, Brazil.

methodsWe evaluated MSM and TGW who sought HIV testing at the Evandro Chagas National Institute of Infectious Diseases-FIOCRUZ between March 2018 and January 2020. The Limiting Avidity assay (LAg) as part of a recent infection testing algorithm (RITA) was employed to identify recent infections (those with a normalized optical density ≤1.5 in the LAg that met all RITA criteria) among those who tested positive for HIV and the annualized HIV incidence was estimated. RESULTS AND DISCUSSION: Out of 3053 individuals assessed, 2591 (84.9%) were HIV negative and 462 (15.1%) were living with HIV. Among these, 302 (65.4%) with stored samples available were evaluated and 73/302 (24.2%) were classified as recent infections. The annualized incidence rate estimate using a false recency rate of zero was 7.35% (95% CI 5.76% to 9.25%).

conclusionsOur results suggest that the HIV epidemic in Rio de Janeiro, Brazil, continues to disproportionately burden vulnerable populations, including MSM and TGW despite the existence and availability of effective preventive and therapeutic interventions.

Indexed as

EpidemicsHIV InfectionsSexual and Gender MinoritiesTransgender PersonsBrazilCross-Sectional StudiesFemaleHomosexuality, MaleHumansMalediagnosisHIVincidenceMSMrecencytrans women

Identifiers

PMID34132470
PMCPMC8207443
OpenAlexW3168121242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.