ArticleHuman brain mapping2021
Supraspinal nociceptive networks in neuropathic pain after spinal cord injury.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Brain morphology changes after spinal cord injury: A voxel-based meta-analysis.Frontiers in neurology · 2022Pooled it
- The hijacked insula: A stratified model of affective touch modulation in chronic pain.Journal of neuropsychology · 2026Review
- Pain integration of multimodal noxious stimulation based on the perceptual instruction.Proceedings. Biological sciences · 2025Article
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Chronic spinal cord injury is associated with morphometric brain changes in functional networks beyond the sensorimotor system.Frontiers in neurology · 2025Article
- Review
- Electroencephalography-based biological and functional characteristics of spinal cord injury patients with neuropathic pain and numbness.Frontiers in neuroscience · 2024Article
- Neuropathic pain relief and altered brain networks after dorsal root entry zone microcoagulation in patients with spinal cord injury.Brain communications · 2024Article
- Central neuropathic pain.Nature reviews. Disease primers · 2023Review
- Sensory phenotypes in complex regional pain syndrome and chronic low back pain-indication of common underlying pathomechanisms.Pain reports · 2023Article
- Intrinsic brain connectivity alterations despite intact pain inhibition in subjects with neuropathic pain after spinal cord injury: a pilot study.Scientific reports · 2023Article
- Review
- Buyang Huanwu Decoction promotes the neurological recovery of traumatic spinal cord injury via inhibiting apoptosis, inflammation, and oxidative stress.Immunity, inflammation and disease · 2023Article
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Noxious radiant heat evokes bi-component nociceptive withdrawal reflexes in spinal cord injured humans-A clinical tool to study neuroplastic changes of spinal neural circuits.Frontiers in human neuroscience · 2023Article
- A shift of brain network hub after spinal cord injury.Frontiers in molecular neuroscience · 2023Article
- Functional connectivity and amplitude of low-frequency fluctuations changes in people with complete subacute and chronic spinal cord injury.Scientific reports · 2022Article
- Indicators of central sensitization in chronic neuropathic pain after spinal cord injury.European journal of pain (London, England) · 2022Article
- NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex.Scientific reports · 2022Article
- Supraspinal nociceptive networks in neuropathic pain after spinal cord injury.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Neuropathic pain following spinal cord injury involves plastic changes along the whole neuroaxis. Current neuroimaging studies have identified grey matter volume (GMV) and resting-state functional connectivity changes of pain processing regions related to neuropathic pain intensity in spinal cord injury subjects. However, the relationship between the underlying neural processes and pain extent, a complementary characteristic of neuropathic pain, is unknown. We therefore aimed to reveal the neural markers of widespread neuropathic pain in spinal cord injury subjects and hypothesized that those with greater pain extent will show higher GMV and stronger connectivity within pain related regions. Thus, 29 chronic paraplegic subjects and 25 healthy controls underwent clinical and electrophysiological examinations combined with neuroimaging. Paraplegics were demarcated based on neuropathic pain and were thoroughly matched demographically. Our findings indicate that (a) spinal cord injury subjects with neuropathic pain display stronger connectivity between prefrontal cortices and regions involved with sensory integration and multimodal processing, (b) greater neuropathic pain extent, is associated with stronger connectivity between the posterior insular cortex and thalamic sub-regions which partake in the lateral pain system and (c) greater intensity of neuropathic pain is related to stronger connectivity of regions involved with multimodal integration and the affective-motivational component of pain. Overall, this study provides neuroimaging evidence that the pain phenotype of spinal cord injury subjects is related to the underlying function of their resting brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.