ArticleHuman brain mapping2021
A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Disruption of temporo-parietal network in Alzheimer's disease and its association with memory impairment.Alzheimer's research & therapy · 2026Observational
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.Scientific reports · 2025Article
- Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults.Alzheimer's research & therapy · 2025Article
- Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal OlderThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Searchlight-based trial-wise fMRI decoding in the presence of trial-by-trial correlations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.Nature communications · 2024Observational
- Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.Brain : a journal of neurology · 2024Article
- Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer's disease risk spectrum.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults.Frontiers in aging neuroscience · 2024Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The relationship between resting-state amplitude fluctuations and memory-related deactivations of the default mode network in young and older adults.Human brain mapping · 2023Article
- Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.Human brain mapping · 2023Article
- Neuroimaging biomarkers of cognitive recovery after ischemic stroke.Frontiers in neurology · 2022Review
- A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging.Human brain mapping · 2021Article
- Globally Aging Cortical Spontaneous Activity Revealed by Multiple Metrics and Frequency Bands Using Resting-State Functional MRI.Frontiers in aging neuroscience · 2021Article
- Learning by Insight-Like Sudden Comprehension as a Potential Strategy to Improve Memory Encoding in Older Adults.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust age-group-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.
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