Evidence map›Paper›PMID 34132416›Full record

ArticleStatistics in medicine2021

Bayesian variable selection for understanding mixtures in environmental exposures.

Daniel R Kowal, Mercedes Bravo, Henry Leong, Alexander Bui, Robert J Griffin, Katherine B Ensor, Marie Lynn Miranda

Abstract read
In one paragraph

Article in Statistics in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Workflow for Statistical Analysis of Environmental Mixtures.Environmental health perspectives · 2026
    Review
  3. Environmental Mixtures Analysis (E-MIX) Workflow and Methods Repository.medRxiv : the preprint server for health sciences · 2024
    Article
  4. Article
  5. Regression with race-modifiers: towards equity and interpretability.medRxiv : the preprint server for health sciences · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Fast, Optimal, and Targeted Predictions using Parametrized Decision Analysis.Journal of the American Statistical Association · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel R KowalDepartment of Statistics, Rice University, Houston, Texas, USA.ORCID 0000-0003-0917-3007
Mercedes BravoBiostatistics and Epidemiology Division, RTI International, Durham, North Carolina, USA.
Henry LeongChildren's Environmental Health Initiative, University of Notre Dame, Notre Dame, Indiana, USA.
Alexander BuiDepartment of Civil and Environmental Engineering, Rice University, Houston, Texas, USA.
Robert J GriffinDepartment of Civil and Environmental Engineering, Rice University, Houston, Texas, USA.
Katherine B EnsorDepartment of Statistics, Rice University, Houston, Texas, USA.ORCID 0000-0002-3964-0465
Marie Lynn MirandaChildren's Environmental Health Initiative, University of Notre Dame, Notre Dame, Indiana, USA.

Funding

Bringing Modern Data Science Tools to Bear on Environmental Mixtures: Administrative Supplement for U3 PopulationsR01ES028819 · NIEHS · UNIVERSITY OF NOTRE DAME · PI MIRANDA, MARIE LYNN · 2018 to 2021
$2.4M
Disparate Exposures, Disparate Outcomes: The Effect of Cumulative DisadvantageR00MD011304 · NIMHD · RESEARCH TRIANGLE INSTITUTE · PI BRAVO, MERCEDES AURELIA · 2019 to 2021
$722k
NIEHS NIH HHS R01 ES028819NIMHD NIH HHS R00 MD011304
6 · The paper itself

Abstract

Social and environmental stressors are crucial factors in child development. However, there exists a multitude of measurable social and environmental factors-the effects of which may be cumulative, interactive, or null. Using a comprehensive cohort of children in North Carolina, we study the impact of social and environmental variables on 4th end-of-grade exam scores in reading and mathematics. To identify the essential factors that predict these educational outcomes, we design new tools for Bayesian linear variable selection using decision analysis. We extract a predictive optimal subset of explanatory variables by coupling a loss function with a novel model-based penalization scheme, which leads to coherent Bayesian decision analysis and empirically improves variable selection, estimation, and prediction on simulated data. The Bayesian linear model propagates uncertainty quantification to all predictive evaluations, which is important for interpretable and robust model comparisons. These predictive comparisons are conducted out-of-sample with a customized approximation algorithm that avoids computationally intensive model refitting. We apply our variable selection techniques to identify the joint collection of social and environmental stressors-and their interactions-that offer clear and quantifiable improvements in prediction of reading and mathematics exam scores.

Indexed as

Environmental ExposureBayes TheoremChildCohort StudiesHumansNorth Carolinaair qualityeducational outcomesleadpredictionregression

Identifiers

PMID34132416
PMCPMC8440371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.