Evidence map›Paper›PMID 34132374›Full record

ArticleMolecular medicine reports2021

Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer.

Hua Yin, Jingjing Hu, Zhiying Ye, Saijun Chen, Yunwen Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  6. Relationship between exosomes and cancer: formation, diagnosis, and treatment.International journal of biological sciences · 2025
    Review
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  8. Multiomic Profiling and Neuroprotective Bioactivity ofInternational journal of nanomedicine · 2024
    Article
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  18. Cross-Talk Between mFrontiers in immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hua YinDepartment of B‑Ultrasonic Room, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Jingjing HuDepartment of B‑Ultrasonic Room, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Zhiying YeDepartment of B‑Ultrasonic Room, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Saijun ChenDepartment of B‑Ultrasonic Room, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Yunwen ChenDepartment of B‑Ultrasonic Room, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
University of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has indicated that long non‑coding RNAs (lncRNAs) serve an essential role in carcinogenesis and cancer development. It has been reported that lncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT‑AS1) serves a crucial role in several types of cancer. However, the clinical significance of circulating NNT‑AS1 expression in colorectal cancer (CRC) remains to be elucidated. The current study aimed to investigate the potential role of NNT‑AS1 and the clinical significance of its serum expression levels in patients with CRC. The expression of NNT‑AS1 was measured in 40 pairs of tumor and adjacent normal tissues from patients with CRC via reverse transcription‑quantitative PCR. The serum expression levels of NNT‑AS1 were assayed in an independent cohort of healthy controls and patients with CRC. The levels of NNT‑AS1 were also compared between paired preoperative and postoperative serum samples. In addition, the presence of exosomal NNT‑AS1 in serum was explored. Furthermore, the biological roles of NNT‑AS1 were investigated in CRC cells

Indexed as

Biomarkers, TumorCell Line, TumorCell MovementCell ProliferationCohort StudiesColorectal NeoplasmsExosomesFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsNADP Transhydrogenasesras ProteinsRNA, AntisenseRNA, Long NoncodingBiomarkers, TumorMicroRNAsMIRN496 microRNA, humanNADP TranshydrogenasesRap2C protein, humanras ProteinsRNA, AntisenseRNA, Long Noncodingbiomarkercolorectal cancerexosomemicroRNA‑496nicotinamide nucleotide transhydrogenase antisense RNA 1Ras‑related protein Rap‑2c

Identifiers

PMID34132374
PMCPMC8222968
OpenAlexW3166088886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.