Evidence map›Paper›PMID 34132369›Full record

ArticleMolecular medicine reports2021

Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway.

Haixia Li, Xiaoyun Shen, Yifan Tong, Tong Ji, Yan Feng, Yanping Tang, Rongyun Mai, Jiaxiang Ye, Ting Que, Xiaoling Luo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Haixia LiDepartment of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Xiaoyun ShenKey Laboratory of Endoscopic Technology Research, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.
Yifan TongKey Laboratory of Endoscopic Technology Research, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.
Tong JiKey Laboratory of Endoscopic Technology Research, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.
Yan FengResearch Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Yanping TangResearch Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Rongyun MaiResearch Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Jiaxiang YeDepartment of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Ting QueDepartment of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Xiaoling LuoDepartment of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Guangxi Medical University · CNTumor Hospital of Guangxi Medical University · CNSir Run Run Shaw Hospital · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia‑reperfusion (IR) injury is a major challenge influencing the outcomes of hepatic transplantation. Transforming growth factor‑β (TGF‑β) and its downstream gene, SMAD family member 3 (Smad3), have been implicated in the pathogenesis of chronic hepatic injuries, such as hepatic fibrosis. Thus, the present study aimed to investigate the role of the TGF‑β/Smad3 signaling pathway on hepatic injury induced by IR

Indexed as

ApoptosisSignal TransductionAlanine TransaminaseAnimalsInflammationLiverLiver CirrhosisMiceMice, 129 StrainMice, KnockoutReperfusion InjurySmad3 ProteinTransforming Growth Factor beta1Alanine TransaminaseSmad3 ProteinSmad3 protein, mouseTransforming Growth Factor beta1hepatic injuryischemia‑reperfusionSmad3 mutant miceSMAD family member 3transforming growth factor‑β

Identifiers

PMID34132369
PMCPMC8223105
OpenAlexW3172131802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.