Evidence map›Paper›PMID 34132355›Full record

ArticleInternational journal of molecular medicine2021

Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway.

Tianyu Sun, Liying Duan, Jiaju Li, Hongyu Guo, Mingyue Xiong

Open access · hybridAbstract read
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tianyu SunDepartment of Traumatology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
Liying DuanDepartment of Basic Medicine, Puyang Medical College, Puyang, Henan 457000, P.R. China.
Jiaju LiDepartment of Traumatology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
Hongyu GuoDepartment of Traumatology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
Mingyue XiongDepartment of Traumatology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
First Affiliated Hospital of Henan University of Science and Technology · CNNanyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gypenoside XVII (GP‑17), one of the dominant active components of

Indexed as

AnimalsApoptosisCell LineCytokinesFemaleGene Expression ProfilingInflammation MediatorsMiceMice, Inbred C57BLMicroRNAsMolecular StructureProtective AgentsProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSaponinsSignal TransductionCytokinesgypenoside XVIIInflammation MediatorsMicroRNAsMIRN21 microRNA, mouseProtective AgentsProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSaponinsTOR Serine-Threonine Kinasesgypenoside XVIImicroRNA‑21PTEN/AKT/mTOR pathwayspinal cord injury

Identifiers

PMID34132355
PMCPMC8208621
OpenAlexW3167078763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.