Evidence map›Paper›PMID 34132175›Full record

ArticlePrion2021

Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues.

Collin C Luk, Candace K Mathiason, Christina D Orrù, Gerard H Jansen, Allison Thiele, Byron Caughey, Valerie L Sim

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Prion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Cellular PrPThe Journal of general virology · 2026
    Article
  3. Article
  4. Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Collin C LukDivision of Neurology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
Candace K MathiasonDepartment of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, CO, USA.
Christina D OrrùLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA.
Gerard H JansenDepartment of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada.
Allison ThieleDepartment of Obstetrics and Gynaecology, Faculty of Medicine & Dentistry, Edmonton, Canada.
Byron CaugheyLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA.
Valerie L SimDivision of Neurology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
University of Alberta · CANational Institute of Allergy and Infectious Diseases · USColorado State University · USUniversity of Ottawa · CA

Funding

Detection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1M
Detection and Characterization of Blood-borne PrionsR01AI112956 · NIAID · COLORADO STATE UNIVERSITY · PI MATHIASON, CANDACE K. · 2014 to 2024
$4.6M
Mother to Offspring Transmission of Chronic Wasting DiseaseR01AI093634 · NIAID · COLORADO STATE UNIVERSITY · PI MATHIASON, CANDACE K. · 2011 to 2015
$2.2M
NIAID NIH HHS R01 AI093634NIAID NIH HHS R01 AI112956
6 · The paper itself

Abstract

Sporadic Creutzfeldt-Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we used sensitive real-time quaking-induced conversion (RT-QuIC) assays to test for the infectious prion protein (PrP

Indexed as

Creutzfeldt-Jakob SyndromePrionsAdultBiological AssayFemaleHumansPlacentaPregnancyPrion ProteinsPrion ProteinsPrionsCreutzfeldt–Jakob diseasepregnancyprionRt-QuICvertical transmission

Identifiers

PMID34132175
PMCPMC8210859
OpenAlexW3166282680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.