Evidence map›Paper›PMID 34132157›Full record

ArticleGut microbes

Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment.

Sukhpreet K Tamana, Hein M Tun, Theodore Konya, Radha S Chari, Catherine J Field, David S Guttman, Allan B Becker, Theo J Moraes, Stuart E Turvey, Padmaja Subbarao and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 4 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 181 citations in OpenAlex.

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  6. Frontiers in immunology · 2022
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Sukhpreet K TamanaDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Hein M TunDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Theodore KonyaDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Radha S ChariDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada.
Catherine J FieldDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB, Canada.
David S GuttmanCentre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON, Canada.
Allan B BeckerDepartment of Pediatrics & Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-4707-8177
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-9968-6601
Stuart E TurveyDepartment of Pediatrics, Child & Family Research Institute, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-1599-1065
Padmaja SubbaraoDepartment of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-0394-1933
Malcolm R SearsDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Jacqueline PeiDepartment of Educational Psychology, University of Alberta, Edmonton, AB, Canada.
James A ScottDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Piush J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-3682-9120
Anita L KozyrskyjDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CAUniversity of Toronto · CAChildren's Hospital Research Institute of Manitoba · CAMcMaster University · CAUniversity of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

Dysbiosis of gut microbiota has been retrospectively linked to autism spectrum disorders but the temporal association between gut microbiota and early neurodevelopment in healthy infants is largely unknown. We undertook this study to determine associations between gut microbiota at two critical periods during infancy and neurodevelopment in a general population birth cohort.Here, we analyzed data from 405 infants (199 females) from the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study. Neurodevelopmental outcomes were objectively assessed using the Bayley Scale of Infant Development (BSID-III) at 1 and 2 years of age. Microbiota profiling with 16S rRNA gene sequencing was conducted on fecal samples obtained at a mean age of 4 and 12 months.Using clustering methods, we identified three groups of infants based on relative abundance of gut microbiota at 12 months:

Indexed as

Child DevelopmentGastrointestinal MicrobiomeBacteriaBacteroidesCanadaFemaleFollow-Up StudiesHumansInfantMaleNervous SystemRetrospective StudiesRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbacteroidetesbirth cohortcognitionearly colonizationgut microbiotaInfantneurodevelopment

Identifiers

PMID34132157
PMCPMC8210878
OpenAlexW3167593620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.