Evidence map›Paper›PMID 34132142›Full record

ArticleJournal of the International Association of Providers of AIDS Care

Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach.

Edward R Cachay, Alvaro Mena, Luis Morano, Laura Benitez, Ivana Maida, Carmen DE Mendoza, Lucas Hill, Francesca Torriani, Vincente Soriano, W C Mathews and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Edward R CachayDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA.ORCID 0000-0002-2452-7558
Alvaro MenaU Enfermedades Infecciosas, S Medicina Interna, University Hospital of La Coruña, Spain.
Luis MoranoUnit of Infectious Diseases, University Hospital Álvaro Cunqueiro; Vigo, Spain.ORCID 0000-0002-0560-3260
Laura BenitezPuerta de Hierro Research Institute and University Hospital, Madrid, Spain.
Ivana MaidaDepartment of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0003-4895-7576
Carmen DE MendozaPuerta de Hierro Research Institute and University Hospital, Madrid, Spain.
Lucas HillSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, CA, USA.
Francesca TorrianiDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA.
Vincente SorianoUNIR Health Sciences School & Medical Center, Madrid, Spain.
W C MathewsDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA.
HCV-HIV Transatlantic Research Network (HCV-TREN)
University of California San Diego · USHospital Universitario Puerta de Hierro Majadahonda · ESUniversidade da Coruña · ESUniversity Hospital Complex Of Vigo · ESUniversity of Sassari · IT

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
NIAID NIH HHS P30 AI036214
6 · The paper itself

Abstract

Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach.

Indexed as

CoinfectionHepatitis CHepatitis C, ChronicHIV InfectionsAntiviral AgentsHepacivirusHumansLiver CirrhosisProspective StudiesTreatment OutcomeAntiviral AgentsDAAHCVHIVliver decompensationmultidisciplinary

Identifiers

PMID34132142
PMCPMC8212364
OpenAlexW3166768615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.