SynthesisEuropean journal of pediatrics2021
The use of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) in neonates: a systematic review.
Synthesis in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Bleeding and Thrombotic Risk in Cirrhosis: Hemostatic Profiles from a Single-Center Experience.Life (Basel, Switzerland) · 2026Article
- Management of neonatal massive hemorrhage: A narrative review.Transfusion · 2026Review
- Neonatal Sepsis-Induced Coagulopathy in the Light of Developmental Hemostasis: Friend or Foe?Medicina (Kaunas, Lithuania) · 2026Review
- Case Report: Managing coagulopathy in neonatal acute liver failure: insights from a case of rebalanced hemostasis and thromboelastography monitoring.Frontiers in pediatrics · 2026Article
- Rotational Thromboelastometry (ROTEM) Hemostasis Profile in Pregnant Women with Preeclampsia and Their Offspring: An Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Hemostasis Laboratory Diagnostics in Newborns.Journal of clinical medicine · 2025Review
- Comparison of standard and global hemostasis assays in cord and peripheral blood of newborns.Pediatric research · 2025Article
- Clinical evaluation of hypercoagulability in advanced malignant tumors using thromboelastography and conventional coagulation tests.Medicine · 2025Observational
- Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy.BJA open · 2024Review
- Associations Between Clinical Factors and Postoperative Thrombosis in Pediatric Cardiac Surgery Patients: A Single-Center Retrospective Study.Critical care explorations · 2024Article
- Fibrinogen contribution to clot strength in patients with sepsis and hematologic malignancies and thrombocytopenia-a prospective, single-center, analytical, cross-sectional study.Research and practice in thrombosis and haemostasis · 2024Article
- Hemostatic Profile of Intrauterine Growth-Restricted Neonates: Assessment with the Use of NATEM Assay in Cord Blood Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Quick model-based viscoelastic clot strength predictions from blood protein concentrations for cybermedical coagulation control.Nature communications · 2024Article
- Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study.Biomarkers in medicine · 2024Article
- Viscoelastic coagulation testing in Neonatal Intensive Care Units: advantages and pitfalls in clinical practice.Blood transfusion = Trasfusione del sangue · 2023Review
- Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study.Blood advances · 2023Article
- Fibrinolysis shutdown and elevated D-dimer levels have high prognostic capacity for postoperative thromboembolic complications in patients with bone tumors.Journal of thrombosis and thrombolysis · 2023Observational
- Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines.Life (Basel, Switzerland) · 2023Review
- Thromboelastography: a review for radiologists and implications on periprocedural bleeding risk.Abdominal radiology (New York) · 2022Review
- Neonatal Sepsis and Hemostasis.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Developmental hemostasis" refers to the dynamic process of gradual hemostatic maturation. Conventional coagulation tests seem to fail to accurately depict the in vivo hemostasis, while viscoelastic tests, thromboelastography (TEG), and rotational thromboelastometry (ROTEM) appear very promising as they provide insight more rapidly and accurately into the hemostatic potential. We systematically reviewed the literature in PubMed to examine the use of TEG and ROTEM in neonates. Our search yielded 34 studies, of which 18 concerned healthy neonates and 16 sick neonates. These viscoelastic tests have shown accelerated initiation of coagulation, increased clot strength, and increased fibrinolysis in healthy neonates compared to children and adults. Cord blood leads to a hypercoagulable state as compared to whole blood when testing is performed with TEG. Pre-term neonates have a more hypocoagulable profile, but balanced hemostasis, related to term neonates, that evolves to a more procoagulant phenotype over the first month of life. Critically ill neonates exhibit a more hypocoagulable profile as compared to healthy neonates. TEG and ROTEM have shown predictive value for bleeding events in critically ill neonates and neonates undergoing cardiopulmonary bypass or therapeutic hypothermia.Conclusion: TEG and ROTEM need to become part of the standard coagulation assessment in clinical settings in which hemostatic abnormalities are involved, as they seem to provide more rapid and accurate information regarding the hemostatic profile of the neonates. Their predictive value for bleeding events in critically ill neonates could lead to a more targeted therapy optimizing utilization of blood products. What is Known: • Conventional coagulation tests seem to fail to accurately depict the in vivo hemostasis. • TEG and ROTEM delineate more rapidly and accurately the hemostatic potential. What is New: • TEG and ROTEM have shown predictive value for bleeding events. • TEG and ROTEM may lead to a more targeted transfusion therapy optimizing utilization of blood products.
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