Evidence map›Paper›PMID 34131651›Full record

ArticleFunction (Oxford, England)2021

Loss of Adam10 Disrupts Ion Transport in Immortalized Kidney Collecting Duct Cells.

Adrienne Assmus, Linda Mullins, Mairi Ward, Ross Dobie, Robert Hunter, Neil C Henderson, John J Mullins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adrienne AssmusUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-2286-0648
Linda MullinsUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
Mairi WardUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
Ross DobieUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
Robert HunterUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0003-2344-8978
Neil C HendersonUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
John J MullinsUniversity of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
British Heart Foundation · GB

Funding

British Heart Foundation RE/08/001/23904Wellcome TrustWellcome Trust 219542/Z/19/Z
6 · The paper itself

Abstract

The kidney cortical collecting duct (CCD) comprises principal cells (PCs), intercalated cells (IC), and the recently discovered intermediate cell type. Kidney pathology in a mouse model of the syndrome of apparent aldosterone excess revealed plasticity of the CCD, with altered PC:intermediate cell:IC ratio. The self-immortalized mouse CCD cell line, mCCD

Indexed as

ADAM10 ProteinKidney Tubules, CollectingAldosteroneAmyloid Precursor Protein SecretasesAnimalsCell LineIon TransportMembrane ProteinsMiceADAM10 ProteinAdam10 protein, mouseAldosteroneAmyloid Precursor Protein SecretasesMembrane ProteinsAdam10 knockoutcell plasticitymCCDcl1 cell line, kidney cortical collecting ductmouse SAME model, CRISPR-Cas9polyploidy

Identifiers

PMID34131651
PMCPMC8187228
OpenAlexW3166340909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.