Evidence map›Paper›PMID 34131644›Full record

ArticleBrain communications2021

Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery.

Edward J Smith, Pamela P Farshim, Rachel Flomen, Samuel T Jones, Sean J McAteer, Benjamin E Deverman, Viviana Gradinaru, Gillian P Bates

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Edward J SmithHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Pamela P FarshimHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-4816-6635
Rachel FlomenHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-6434-5804
Samuel T JonesHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Sean J McAteerHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Benjamin E DevermanThe Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91101, USA.
Gillian P BatesHuntington's Disease Centre, Department of Neurodegenerative Disease, UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-4041-6305
UK Dementia Research Institute · GBBroad Institute · USCalifornia Institute of Technology · US

Funding

Neuromodulation and Neurodegeneration: the Missing Link and Mechanisms of ActionDP2NS087949 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA · 2013 to 2019
$4.1M
Medical Research Council MR/M02492X/1NINDS NIH HHS DP2 NS087949
6 · The paper itself

Abstract

The engineering of the AAV-PHP capsids was an important development for CNS research and the modulation of gene expression in the brain. They cross the blood brain barrier and transduce brain cells after intravenous systemic delivery, a property dependent on the genotype of

Indexed as

AAV-PHP virusesCNS transductiongene therapyhigh-content imagingLy6a inbred strain variants

Identifiers

PMID34131644
PMCPMC8200048
OpenAlexW3163658013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.