Evidence map›Paper›PMID 34131556›Full record

ArticleNetwork modeling and analysis in health informatics and bioinformatics2021

Molecular docking and dynamics studies of curcumin with COVID-19 proteins.

Renuka Suravajhala, Abhinav Parashar, Gourav Choudhir, Anuj Kumar, Babita Malik, Viswanathan Arun Nagaraj, Govindarajan Padmanaban, Rathnagiri Polavarapu, Prashanth Suravajhala, P B Kavi Kishor

Open access · bronzeAbstract read
In one paragraph

Article in Network modeling and analysis in health informatics and bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Are Antiviral Flavonoids Part of the Solution to the COVID-19 Pandemic?Integrative medicine (Encinitas, Calif.) · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Renuka Suravajhala *Department of Chemistry, Manipal University Jaipur, Jaipur, 303 007 Rajasthan India.ORCID https://orcid.org/0000-0002-4088-5785
Abhinav Parashar *Department of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed To Be University), Vadlamudi, Guntur, 522 213 Andhra Pradesh India.
Gourav ChoudhirCentre for Rural Development and Technology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110 016 India.
Anuj KumarBioinformatics Laboratory, Uttarakhand Council for Biotechnology (UCB), Biotech Bhawan, Haldi, U.S. Nagar, Pantnagar, 263 145 Uttarakhand India.ORCID https://orcid.org/0000-0002-5023-7618
Babita MalikDepartment of Chemistry, Manipal University Jaipur, Jaipur, 303 007 Rajasthan India.
Viswanathan Arun NagarajInstitute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, 751 023 Odisha India.
Govindarajan PadmanabanIndian Institute of Science, Bengaluru, 560 012 India.
Rathnagiri PolavarapuGenomix CARL Pvt. Ltd., Pulivendula, Kadapa, 516 390 Andhra Pradesh India.
Prashanth SuravajhalaDepartment of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur, 320 001 Rajasthan India.ORCID 0000-0002-8535-278X
P B Kavi KishorDepartment of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed To Be University), Vadlamudi, Guntur, 522 213 Andhra Pradesh India.
Manipal University JaipurVignan's Foundation for Science, Technology & Research · INBirla Institute of Scientific Research · INGenomix Biotech (India) · INIndian Institute of Science Bangalore · INIndian Institute of Technology Delhi · INInstitute of Life Sciences · INUttarakhand State Council for Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is caused by a Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), which is a positive-strand RNA virus. The SARS-CoV-2 genome and its association to SAR-CoV-1 vary from ca. 66 to 96% depending on the type of betacoronavirideae family members. With several drugs, viz. chloroquine, hydroxychloroquine, ivermectin, artemisinin, remdesivir, azithromycin considered for clinical trials, there has been an inherent need to find distinctive antiviral mechanisms of these drugs. Curcumin, a natural bioactive molecule has been shown to have therapeutic potential for various diseases, and its effect on COVID-19 is also currently being explored. In this study, we show the binding potential of curcumin targeted to a variety of SARS-CoV-2 proteins, viz

Indexed as

Antiviral mechanismCOVID-19CurcuminMembrane glycoproteinnsp10Nucleocapsid phosphoprotein

Identifiers

PMID34131556
PMCPMC8192041
OpenAlexW3167910883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.