Evidence map›Paper›PMID 34131512›Full record

ArticleVirus evolution2021

Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms during the 2014-15 influenza season.

Deena R Blumenkrantz, Thomas Mehoke, Kathryn Shaw-Saliba, Harrison Powell, Nicholas Wohlgemuth, Hsuan Liu, Elizabeth Macias, Jared Evans, Mitra Lewis, Rebecca Medina and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. 2019-20 H1N1 clade A5a.1 viruses have betterbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Deena R BlumenkrantzW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.ORCID https://orcid.org/0000-0002-3400-657X
Thomas MehokeResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.ORCID https://orcid.org/0000-0001-6607-8925
Kathryn Shaw-SalibaW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.
Harrison PowellW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.
Nicholas WohlgemuthW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.ORCID https://orcid.org/0000-0002-6450-6452
Hsuan LiuW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.
Elizabeth MaciasEpidemiology Laboratory Service, United States Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, OH, USA.
Jared EvansResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.
Mitra LewisDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rebecca MedinaDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin HardickDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lauren M SauerDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrea DugasDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anna DuValDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew P LaneDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-6369-5469
Charlotte GaydosDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Richard RothmanDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter ThielenResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.ORCID https://orcid.org/0000-0003-1807-2785
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health,Laurel, MD, USA.ORCID https://orcid.org/0000-0003-3248-1761

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
NIAID NIH HHS HHSN272201400007CNIAID NIH HHS T32 AI007417
6 · The paper itself

Abstract

The 2014-15 influenza season saw the emergence of an H3N2 antigenic drift variant that formed the 3C.2a HA clade. Whole viral genomes were sequenced from nasopharyngeal swabs of ninety-four patients with confirmed influenza A virus infection and primary human nasal epithelial cell cultures used to efficiently isolate H3N2 viruses. The isolates were classified by HA clade and the presence of a new set of co-selected mutations in NA (a glycosylation site, NAg+) and PB1-F2 (H75P). The NA and PB1-F2 mutations were present in a subset of clade 3C.2a viruses (NAg+F2P), which dominated during the subsequent influenza seasons. In human nasal epithelial cell cultures, a virus with the novel NAg+F2P genotype replicated less well compared with a virus with the parental genotype. Retrospective analyses of clinical data showed that NAg+F2P genotype viruses were associated with increased cough and shortness of breath in infected patients.

Indexed as

antigenic driftH3N2humaninfluenzaNAPB1-F2symptoms

Identifiers

PMID34131512
PMCPMC8197029

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.