Evidence map›Paper›PMID 34131415›Full record

ArticleContrast media & molecular imaging2021

Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles.

Yang Li, Chao Feng Yang, Hui Zuo, Ao Li, Sushant Kumar Das, Jin Hong Yu

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Quantitative imaging in medicine and surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang LiDepartment of Radiology, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong City, Sichuan Province 637000, China.ORCID 0000-0002-1491-4642
Chao Feng YangDepartment of Radiology, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong City, Sichuan Province 637000, China.ORCID 0000-0002-2490-2565
Hui ZuoDepartment of Ultrasound, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong City, Sichuan Province 637000, China.ORCID 0000-0002-5659-9548
Ao LiDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing City, Jiangsu Province 210000, China.ORCID 0000-0002-0442-7170
Sushant Kumar DasDepartment of Radiology, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong City, Sichuan Province 637000, China.ORCID 0000-0001-6746-6938
Jin Hong YuDepartment of Ultrasound, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong City, Sichuan Province 637000, China.ORCID 0000-0003-4988-7696
Affiliated Hospital of North Sichuan Medical College · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The decrease in asialoglycoprotein receptor (ASGPR) levels is observed in patients with chronic liver disease and liver tumor. The aim of our study was to develop ASGPR-targeted superparamagnetic perfluorooctylbromide nanoparticles (M-PFONP) and wonder whether this composite agent could target buffalo rat liver (BRL) cells in vitro and could improve Methods: GalPLL, a ligand of ASGPR, was synthesized by reductive amination. ASGPR-targeted M-PFOBNP was prepared by a film hydration method coupled with sonication. Several analytical methods were used to investigate the characterization and safety of the contrast agent in vitro. The in vivo MR Results: The optimum concentration of Fe Conclusions: GalPLL/M-PFOBNP may potentially serve as a liver-targeted contrast agent for MR receptor imaging.

Indexed as

AnimalsAsialoglycoprotein ReceptorFluorocarbonsHepatocytesHumansHydrocarbons, BrominatedLigandsLiverLiver DiseasesLiver NeoplasmsMagnetic Iron Oxide NanoparticlesRatsAsialoglycoprotein ReceptorFluorocarbonsHydrocarbons, BrominatedLigandsperflubron

Identifiers

PMID34131415
PMCPMC8181107
OpenAlexW3168430809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.