Evidence map›Paper›PMID 34131268›Full record

ReviewMolecular psychiatry2022

Neuroadaptations and TGF-β signaling: emerging role in models of neuropsychiatric disorders.

Swarup Mitra, Craig Werner, David M Dietz

Open access · greenAbstract readReview
In one paragraph

Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  14. The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Swarup MitraDepartment of Pharmacology and Toxicology; Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.
Craig WernerDepartment of Pharmacology and Toxicology; Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.
David M DietzDepartment of Pharmacology and Toxicology; Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA. ddietz@buffalo.edu.ORCID http://orcid.org/0000-0002-6927-9236
Buffalo State University · USNational Institutes of Health · USUniversity at Buffalo, State University of New York · US

Funding

Heroin-Induced genomic regulation of Ventral Pallidum neuron subtypesU01DA051947 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI AMENT, SETH ABRAMS, DIETZ, DAVID M · 2020 to 2024
$3.1M
Cocaine-induced neuroplasticity: a new role for TGF beta signalingR01DA037257 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DIETZ, DAVID M · 2014 to 2018
$2.1M
Heroin-induced plasticity: the role of actin dynamicsR01DA046818 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DIETZ, DAVID M · 2019 to 2024
$1.8M
Neuron Subtype Translatomics in Opiate AbuseR21DA048554 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI DIETZ, DAVID M, LOBO, MARY KAY · 2019 to 2020
$445k
Long-term abstinence and relapse: a novel role for hippocampal activin signalingR21DA044486 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DIETZ, DAVID M · 2017 to 2018
$395k
NIDA NIH HHS R01 DA037257NIDA NIH HHS R01 DA046818NIDA NIH HHS R21 DA044486NIDA NIH HHS R21 DA048554NIDA NIH HHS U01 DA051947
6 · The paper itself

Abstract

Neuropsychiatric diseases are manifested by maladaptive behavioral plasticity. Despite the greater understanding of the neuroplasticity underlying behavioral adaptations, pinpointing precise cellular mediators has remained elusive. This has stymied the development of pharmacological interventions to combat these disorders both at the level of progression and relapse. With increased knowledge on the putative role of the transforming growth factor (TGF- β) family of proteins in mediating diverse neuroadaptations, the influence of TGF-β signaling in regulating maladaptive cellular and behavioral plasticity underlying neuropsychiatric disorders is being increasingly elucidated. The current review is focused on what is currently known about the TGF-β signaling in the central nervous system in mediating cellular and behavioral plasticity related to neuropsychiatric manifestations.

Indexed as

Mental DisordersNervous System DiseasesSignal TransductionTransforming Growth Factor betaCentral Nervous SystemHumansNeuronal PlasticityTransforming Growth Factor beta

Identifiers

PMID34131268
PMCPMC8671568
OpenAlexW3167527434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.