Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor.

C J Martin, F J Veldman, D Labadarios, Z Ebrahim, E Muller, S M Kassier

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Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

0.2field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

C J MartinDepartment of Human Nutrition, Faculty of Health Sciences, Room 4-14, HW, Snyman Building (South), University of Pretoria, Bophelo Road, Gezina, Private Bag X323, Pretoria, 0031, South Africa. claire.martin@up.ac.za.

F J VeldmanDepartment of Human Nutrition and Dietetics Registry, Sefako Makgatho Health Sciences University (Medunsa), P.O Box 60, Pretoria, 0204, South Africa.

D LabadariosProfessor Emeritus, Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Private Bag X1, Matieland, Western Cape, 7602, South Africa.

Z EbrahimDivision of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Private Bag X1, Matieland, Western Cape, 7602, South Africa.

E MullerDepartment of Surgery, University of Cape Town, Private Bag X3, Rondebosch, Cape Town, Western Cape, 7701, South Africa.

S M KassierDepartment of Dietetics and Human Nutrition, School of Agricultural, Earth and Environmental Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209, South Africa.

Stellenbosch University · ZASefako Makgatho Health Sciences University · ZAUniversity of Cape Town · ZAUniversity of KwaZulu-Natal · ZAUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.

Indexed as

AdultFemaleGastrointestinal DiseasesGastrointestinal TractHIV InfectionsHumansImmunosuppressive AgentsKidney DiseasesKidney TransplantationMaleMiddle AgedQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesTissue DonorsTransplant RecipientsImmunosuppressive Agents

Identifiers

PMID34131245

DOI10.1038/s41598-021-92016-2

PMCPMC8206362

OpenAlexW3167656326

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.