Evidence map›Paper›PMID 34131243›Full record

ArticleScientific reports2021

Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.

Yoshinori Takashima, Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yoshinori TakashimaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Shinya HayashiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan. s11793290@yahoo.co.jp.
Koji FukudaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Toshihisa MaedaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Masanori TsubosakaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Tomoyuki KamenagaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Kenichi KikuchiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Masahiro FujitaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Yuichi KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Shingo HashimotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Naoki NakanoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Tomoyuki MatsumotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-chou, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidB7-2 AntigenCalcium-Binding ProteinsCartilageCyclin-Dependent Kinase Inhibitor p21Gene Expression RegulationGenetic Predisposition to DiseaseHumansInflammationInterleukin-1betaInterleukin-6Knee JointMatrix MetalloproteinasesMiceAdgre1 protein, mouseB7-2 AntigenCalcium-Binding ProteinsCyclin-Dependent Kinase Inhibitor p21Interleukin-1betaInterleukin-6Matrix MetalloproteinasesReceptors, G-Protein-CoupledTumor Necrosis Factor-alpha

Identifiers

PMID34131243
PMCPMC8206139
OpenAlexW3168841087

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.