ArticleScientific reports2021
Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Functional ultrasound imaging in preclinical brain stimulation: from multimodal readouts to closed-loop neuromodulation.Frontiers in neuroscience · 2026Review
- A flexible photoacoustic retinal prosthesis.Nature communications · 2025Article
- A flexible photoacoustic retinal prosthesis.bioRxiv : the preprint server for biology · 2025Article
- Robust single-trial decoding of physical self-motion from hemodynamic signals in the brain measured by functional ultrasound imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Optical Devices for the Diagnosis and Management of Spinal Cord Injuries: A Review.Biosensors · 2024Review
- Non-Invasive Hybrid Ultrasound Stimulation of Visual Cortex In Vivo.Bioengineering (Basel, Switzerland) · 2023Article
- [The developments and applications of functional ultrasound imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Review
- Altered Cortical Trigeminal Fields Excitability by Spreading Depolarization Revealed withThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cranial and Spinal Window Preparation forExperimental neurobiology · 2022Review
- Article
- Vision Restoration by Optogenetic Therapy and Developments Toward Sonogenetic Therapy.Translational vision science & technology · 2022Article
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Authors and funding
15 authors.
Funding
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Abstract
Optogenetics has revolutionized neurosciences by allowing fine control of neuronal activity. An important aspect for this control is assessing the activation and/or adjusting the stimulation, which requires imaging the entire volume of optogenetically-induced neuronal activity. An ideal technique for this aim is fUS imaging, which allows one to generate brain-wide activation maps with submesoscopic spatial resolution. However, optical stimulation of the brain with blue light might lead to non-specific activations at high irradiances. fUS imaging of optogenetic activations can be obtained at these wavelengths using lower light power (< 2mW) but it limits the depth of directly activatable neurons from the cortical surface. Our main goal was to report that we can detect specific optogenetic activations in V1 even in deep layers following stimulation at the cortical surface. Here, we show the possibility to detect deep optogenetic activations in anesthetized rats expressing the red-shifted opsin ChrimsonR in V1 using fUS imaging. We demonstrate the optogenetic specificity of these activations and their neuronal origin with electrophysiological recordings. Finally, we show that the optogenetic response initiated in V1 spreads to downstream (LGN) and upstream (V2) visual areas.
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