ArticleScientific reports2021
Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of physical activity interventions on physical and mental health of the elderly: a systematic review and meta-analysis.Aging clinical and experimental research · 2025Pooled it
- Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- The relationship of Systemic Inflammatory Index with asthma in adults: A retrospective cross-sectional study.The Journal of international medical research · 2025Article
- Obesity indicators and female asthma risk: the mediating role of white blood cell count based on NHANES data analysis.BMC pulmonary medicine · 2025Article
- Observational
- Associations of leisure-time and occupational physical activity with allergic rhinitis and chronic sinusitis in middle-aged adults: a population-based study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older.Frontiers in aging · 2025Article
- Systemic immune-inflammation index as a versatile biomarker in autoimmune disorders: insights from rheumatoid arthritis, lupus, and spondyloarthritis.Frontiers in immunology · 2025Review
- Cumulative behavioral and metabolic determinants of health are associated with higher inflammation-related indices: insights from a cross-sectional study (NHANES 2005-2018).Frontiers in public health · 2025Article
- Systemic inflammation markers (SII and SIRI) as predictors of cognitive performance: evidence from NHANES 2011-2014.Frontiers in neurology · 2025Article
- Association of healthy lifestyles with risk of all-cause and cause-specific mortality among individuals with metabolic dysfunction-associated steatotic liver disease: results from the DFTJ cohort.Annals of medicine · 2024Article
- Systemic immunoinflammatory indexes in albuminuric adults are negatively associated with α-klotho: evidence from NHANES 2007-2016.Renal failure · 2024Article
- Interactive association of metals and Life's Essential 8 with mortality in U.S. adults: a prospective cohort study from the NHANES dataset.BMC public health · 2024Article
- Combined influence of physical activity and C-reactive protein to albumin ratio on mortality among older cancer survivors in the United States: a prospective cohort study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Associations between trans fatty acids and systemic immune-inflammation index: a cross-sectional study.Lipids in health and disease · 2024Article
- NHANES-based analysis of the correlation between leisure-time physical activity, serum cotinine levels and periodontitis risk.BMC oral health · 2024Article
- Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia.Heliyon · 2024Article
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- Article
- Association between systemic immune-inflammation index and insulin resistance and mortality.Scientific reports · 2024Article
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15 authors.
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Abstract
Systemic immune-inflammation index (SII) emerged as a biomarker of chronic inflammation and an independent prognostic factor for many cancers. We aimed to investigate the associations of SII level with total and cause-specific mortality risks in the general populations, and the potential modification effects of lifestyle-related factors on the above associations. In this study, we included 30,521 subjects from the Dongfeng-Tongji (DFTJ) cohort and 25,761 subjects from the National Health and Nutrition Examination Survey (NHANES) 1999-2014. Cox proportional hazards regression models were used to estimate the associations of SII with mortality from all-cause, cardiovascular diseases (CVD), cancer and other causes. In the DFTJ cohort, compared to subjects in the low SII subgroup, those within the middle and high SII subgroups had increased risks of total mortality [hazard ratio, HR (95% confidence interval, CI) = 1.12 (1.03-1.22) and 1.26 (1.16-1.36), respectively) and CVD mortality [HR (95%CI) = 1.36 (1.19-1.55) and 1.50 (1.32-1.71), respectively]; those within the high SII subgroup had a higher risk of other causes mortality [HR (95%CI) = 1.28 (1.09-1.49)]. In the NHANES 1999-2014, subjects in the high SII subgroup had higher risks of total, CVD, cancer and other causes mortality [HR (95%CI) = 1.38 (1.27-1.49), 1.33 (1.11-1.59), 1.22 (1.04-1.45) and 1.47 (1.32-1.63), respectively]. For subjects with a high level of SII, physical activity could attenuate a separate 30% and 32% risk of total and CVD mortality in the DFTJ cohort, and a separate 41% and 59% risk of total and CVD mortality in the NHANES 1999-2014. Our study suggested high SII level may increase total and CVD mortality in the general populations and physical activity exerted a beneficial effect on the above associations.
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