Evidence map›Paper›PMID 34131163›Full record

ArticleScientific reports2021

Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach.

Rustin G Kashani, Marcel C Młyńczak, David Zarabanda, Paola Solis-Pazmino, David M Huland, Iram N Ahmad, Surya P Singh, Tulio A Valdez

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06944795 (A Short Wave Infrared Otoscope for Objective Middle Ear Effusion Diagnosis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06944795 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Short Wave Infrared Otoscope for Objective Middle Ear Effusion Diagnosis

TypeinterventionalSponsorStanford UniversityRan2026 to 2027Enrolled100ConditionsOtitis Media, Otitis Media Chronic, Otitis Media EffusionArmsSWIR device
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Rustin G KashaniDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Palo Alto, CA, 94304, USA. rkashani@stanford.edu.
Marcel C MłyńczakInstitute of Metrology and Biomedical Engineering, Faculty of Mechatronics, Warsaw University of Technology, Warsaw, Poland.
David ZarabandaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Palo Alto, CA, 94304, USA.
Paola Solis-PazminoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Palo Alto, CA, 94304, USA.
David M HulandDepartment of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
Iram N AhmadDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Palo Alto, CA, 94304, USA.
Surya P SinghDepartment of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, Karnataka, India.
Tulio A ValdezDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Palo Alto, CA, 94304, USA. tvaldez1@stanford.edu.
Stanford University · USLucile Packard Children's Hospital · USIndian Institute of Technology Dharwad · INWarsaw University of Technology · PL

Funding

Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
NCI NIH HHS T32 CA118681
6 · The paper itself

Abstract

Otitis media, a common disease marked by the presence of fluid within the middle ear space, imparts a significant global health and economic burden. Identifying an effusion through the tympanic membrane is critical to diagnostic success but remains challenging due to the inherent limitations of visible light otoscopy and user interpretation. Here we describe a powerful diagnostic approach to otitis media utilizing advancements in otoscopy and machine learning. We developed an otoscope that visualizes middle ear structures and fluid in the shortwave infrared region, holding several advantages over traditional approaches. Images were captured in vivo and then processed by a novel machine learning based algorithm. The model predicts the presence of effusions with greater accuracy than current techniques, offering specificity and sensitivity over 90%. This platform has the potential to reduce costs and resources associated with otitis media, especially as improvements are made in shortwave imaging and machine learning.

Indexed as

Machine LearningAlgorithmsEar, MiddleHumansOtitis MediaOtitis Media with EffusionOtoscopyRadio Waves

Identifiers

PMID34131163
PMCPMC8206083
OpenAlexW3170293254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.